Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs

The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (miRs) following FMT for rCDI. MethodsSera from two prospective multicentre randomized controlled trials were analyzed for miRNA levels using the Nanostring nCounter platform and quantitative …

Continue reading Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs

Fecal #Microbiota Transplant is Highly Effective in Real-World Practice: Initial Results from the FMT National Registry

Fecal microbiota transplantation (FMT) is commonly used for treatment of C. difficile infections (CDI), although prospective safety data are limited and real-world FMT practice and outcomes are not well described. The FMT National Registry was designed to assess FMT methods and both safety and effectiveness outcomes from North American FMT providers.. ..Of the first 259 …

Continue reading Fecal #Microbiota Transplant is Highly Effective in Real-World Practice: Initial Results from the FMT National Registry

Long-term benefit of #Microbiota Transfer Therapy on #autism symptoms and gut microbiota

Many studies have reported abnormal gut microbiota in individuals with Autism Spectrum Disorders (ASD), suggesting a link between gut microbiome and autism-like behaviors. Modifying the gut microbiome is a potential route to improve gastrointestinal (GI) and behavioral symptoms in children with ASD, and fecal microbiota transplant could transform the dysbiotic gut microbiome toward a healthy …

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Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant

Fecal microbiota transplantation (#FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor …

Continue reading Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant