Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease

Clostridioides difficile infection (CDI) is a major cause of morbidity among patients with inflammatory bowel disease (IBD). Diagnostic biomarkers for early detection of CDI are needed in clinical practice. The relationship between serum procalcitonin and CDI in IBD patients has not been investigated so far. Therefore, we aimed to evaluate the usefulness of measuring serum …

Continue reading Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease

Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs

The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (miRs) following FMT for rCDI. MethodsSera from two prospective multicentre randomized controlled trials were analyzed for miRNA levels using the Nanostring nCounter platform and quantitative …

Continue reading Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs

Fecal #Microbiota Transplant is Highly Effective in Real-World Practice: Initial Results from the FMT National Registry

Fecal microbiota transplantation (FMT) is commonly used for treatment of C. difficile infections (CDI), although prospective safety data are limited and real-world FMT practice and outcomes are not well described. The FMT National Registry was designed to assess FMT methods and both safety and effectiveness outcomes from North American FMT providers.. ..Of the first 259 …

Continue reading Fecal #Microbiota Transplant is Highly Effective in Real-World Practice: Initial Results from the FMT National Registry