Sarcopenia, characterized by the loss of muscle mass and strength, is a multifactorial disorder, including metabolic disturbance. Plasma amino acids (AAs) regulate muscle protein synthesis and breakdown. This study evaluated plasma AA metabolites as potential biomarkers for sarcopenia using metabolomic analysis. We assessed 31 AA metabo lites in an age-matched discovery cohort (72 men, 36… Continue reading #Amino acid metabolites as potential circulating biomarkers for #sarcopenia
Associations of #Wearable- Measured #Sleep and #Physical Activity With #Memory Performance in Older Adults: Cross-Sectional Study With Actigraphy and MRI
Background: Cognitive decline is a common aspect of aging, and identifying modifiable lifestyle factors-such as physical activity and sleep-are crucial for promoting healthy brain aging. While both are individually linked to cognition, few studies have simultaneously assessed their independent and combined effects using objective wearable-based data, particularly in older Asian populations.Objective: This study aimed to… Continue reading Associations of #Wearable- Measured #Sleep and #Physical Activity With #Memory Performance in Older Adults: Cross-Sectional Study With Actigraphy and MRI
Factors associated with the failure to achieve nocturnal blood #pressure control
Background: The Hiroshima Registry for Evaluation and Treatment of Nocturnal and Early Morning Hypertension (Hiroshima NOCTURNE) was a prospective, multicenter study designed to determine whether elevated nighttime blood pressure (BP), assessed using a home BP monitoring (HBPM) device, can be normalized through active antihypertensive therapy in patients already receiving antihypertensive medication. In this subanalysis, we… Continue reading Factors associated with the failure to achieve nocturnal blood #pressure control
Association Between Wake-Time #Movement Behaviors and #Weight Loss Maintenance
We examined whether wake-time movement composition was associated with weight loss maintenance among individuals who experienced clinically meaningful weight loss (> 5% of initial weight) using compositional data analysis.MethodsThis was a secondary analysis from a behavioral weight loss maintenance intervention on weight regain over 12 months following clinically meaningful 3-month weight loss. Body weight was assessed… Continue reading Association Between Wake-Time #Movement Behaviors and #Weight Loss Maintenance
#Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation.… Continue reading #Adenosine as the metabolic common path of rapid #antidepressant action: The #coffee paradox
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Key PointsQuestion Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk of recurrent atrial fibrillation (AF) episodes?Findings In this multicenter randomized clinical trial including 200 patients with persistent AF undergoing cardioversion, the risk of recurrent AF was significantly lower in the group allocated to coffee consumption (47%) compared with… Continue reading Caffeinated Coffee Consumption or Abstinence to Reduce Atrial FibrillationThe DECAF Randomized Clinical Trial
Real-World #Edoxaban Concentrations in #Older Patients Receiving Reduced-Dose Regimens
This study investigated real-world edoxaban concentrations across different dosing regimens, with a specific focus on patients who met the inclusion criteria of low-dose edoxaban for the Elder Care Atrial Fibrillation (ELDERCARE-AF) trial. Patients with atrial fibrillation receiving edoxaban were enrolled to measure trough concentrations. The levels were compared with the expected therapeutic range (12–43 ng/mL) to… Continue reading Real-World #Edoxaban Concentrations in #Older Patients Receiving Reduced-Dose Regimens
#Tetrachloroethylene Is Associated With Presence of Significant Liver #Fibrosis: A National Cross-Sectional Study in US Adults
Background & AimsTetrachloroethylene (PCE) is a volatile organic compound (VOC) used in industrial settings. Pre-clinical studies have linked PCE to hepatotoxicity, but clinical data beyond selected occupational cohorts represent a critical knowledge gap.MethodsWe utilised data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020, a nationally representative survey of the US… Continue reading #Tetrachloroethylene Is Associated With Presence of Significant Liver #Fibrosis: A National Cross-Sectional Study in US Adults
Physical #activity as a modifiable risk factor in preclinical #Alzheimer’s disease
Physical inactivity is a recognized modifiable risk factor for Alzheimer’s disease (AD), yet its relationship with progression of AD pathology in humans remains unclear, limiting the effective translation into prevention trials. Using pedometer-measured step counts in cognitively unimpaired older adults, we demonstrated an association between higher physical activity and slower cognitive and functional decline in… Continue reading Physical #activity as a modifiable risk factor in preclinical #Alzheimer’s disease
2 Medical News 