Importance Active travel modes, such as walking and cycling, are feasible and readily embraced forms of physical activity, but their association with dementia risk and brain structure remains unclear.Objectives To investigate the long-term association between travel modes and dementia risk and brain structural metrics and to evaluate whether genetic predisposition could modify the association between… Continue reading Active #Travel Mode and Incident #Dementia and #Brain Structure
#Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related #Macular #Degeneration
Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are extensively used in treating diabetes and obesity, yet little is known about the long-term ocular effects of systemic prolonged exposure.Objective To evaluate the risk of developing neovascular age-related macular degeneration (nAMD) associated with the use of GLP-1 RAs in patients with diabetes.Design, Setting, and Participants This population-based,… Continue reading #Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related #Macular #Degeneration
Association of #plant -based diets with subclinical #cardiovascular disease in U.S. adults, 1999-2004
BackgroundDietary patterns currently recommended for cardiovascular health often emphasize the consumption of plant foods.MethodsWe included 7,708 participants from the National Health and Nutrition Examination Survey 1999-2004 aged ≥20 years who were not pregnant and did not have a self-reported history of cardiovascular disease. Dietary intake was assessed using a 24-hour dietary recall. All plant-based dietary… Continue reading Association of #plant -based diets with subclinical #cardiovascular disease in U.S. adults, 1999-2004
Volume and Intensity of #Walking and Risk of Chronic Low #Back #Pain
Importance Chronic low back pain (LBP) is a prevalent and costly condition, and regular physical activity may reduce its risk. Walking is a common and accessible form of physical activity, but its association with the risk of chronic LBP is unclear.Objective To examine whether accelerometer-derived daily walking volume and walking intensity are associated with the… Continue reading Volume and Intensity of #Walking and Risk of Chronic Low #Back #Pain
Social #anxiety disorder-associated gut #microbiota increases #social #fear
Understanding the biological basis of social anxiety disorder (SAD), one of the most disabling of the anxiety disorders, will allow for novel treatment strategies to be developed. Here, we show that gut microbiota may be such a target. Mice that received SAD patient microbiota had a specific heightened sensitivity to social fear without affecting other… Continue reading Social #anxiety disorder-associated gut #microbiota increases #social #fear
Contribution of Modifiable Midlife and Late-Life #Vascular Risk Factors to Incident #Dementia
Importance Midlife vascular risk factors are associated with an elevated risk of dementia. However, the total contribution of vascular risk factors in midlife and late life with incident dementia is uncertain.Objective To quantify the proportion of incident dementia attributable to modifiable vascular risk factors measured in midlife and late life and to examine differences by… Continue reading Contribution of Modifiable Midlife and Late-Life #Vascular Risk Factors to Incident #Dementia
Short-Term Cardiometabolic Response to #Mango Intake in Post #menopausal #Women
Consumption of mangos has been associated with improved diet quality, with reported reductions in systolic blood pressure and inflammatory biomarkers when consumed daily in robust amounts for six to eight weeks. Whether these changes could occur with a shorter intake period is unknown.MethodsThis study explored the effect of two weeks of mango intake (330 g/d) on… Continue reading Short-Term Cardiometabolic Response to #Mango Intake in Post #menopausal #Women
Efficiency and Quality of Generative #AI–Assisted #Radiograph Reporting
Question Is clinical use of artificial intelligence (AI)–generated draft radiograph reports associated with documentation efficiency, clinical accuracy, textual quality, and ability to promptly detect pneumothorax requiring intervention?Findings In this cohort study, in 11 980 model-assisted radiograph interpretations in live clinical care, model use was associated with a 15.5% documentation efficiency improvement, with no change in radiologist-evaluated… Continue reading Efficiency and Quality of Generative #AI–Assisted #Radiograph Reporting
Structured #Exercise after Adjuvant Chemotherapy for #Colon #Cancer
Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking.MethodsIn this phase 3, randomized trial conducted at 55 centers, we assigned patients with resected colon cancer who had completed adjuvant chemotherapy to participate in a structured exercise program (exercise group) or to receive health-education materials alone (health-education… Continue reading Structured #Exercise after Adjuvant Chemotherapy for #Colon #Cancer
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