Previous research suggests detrimental health effects associated with consuming processed foods, including processed meats, sugar-sweetened beverages (SSBs) and trans fatty acids (TFAs). However, systematic characterization of the dose–response relationships between these foods and health outcomes is limited. Here, using Burden of Proof meta-regression methods, we evaluated the associations between processed meat, SSBs and TFAs and… Continue reading Health effects associated with consumption of #processed #meat, #sugar -sweetened beverages and trans #fatty acids: a Burden of Proof study
The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
Camel milk has demonstrated robust immunomodulatory and anti-inflammatory properties in various clinical and experimental studies. However, no previous studies have characterized the cellular immunological effects of camel milk in the context of allergic asthma. Therefore, the present work aimed to evaluate the protective effects of camel milk in house dust mite induced asthma in mice,… Continue reading The effect of #camel #milk on house dust mite allergen induced #asthma model in BALB/C mice
Personal night #light exposure predicts incidence of #cardiovascular diseases in >88,000 individuals
Importance Light at night causes circadian disruption, which is a known risk factor for adverse cardiovascular outcomes. However, it is not well understood whether personal light exposure patterns predicts and individual’s risk of cardiovascular diseases.Objective To assess whether day and night light exposure predicts incidence of cardiovascular diseases, and whether relationships of light with cardiovascular… Continue reading Personal night #light exposure predicts incidence of #cardiovascular diseases in >88,000 individuals
Uncertain Benefits of Oral #Vancomycin for Prevention of Recurrent #Clostridioides difficile Infection
Clostridioides difficile infection (CDI) is the most common cause of health care–associated diarrhea, with the primary risk being the use of antibacterial drugs. Approximately 25% of first episodes of CDI are associated with a recurrence; recurrence rates increase with each episode and can be greater than 65%.1 There is no proven strategy to prevent recurrent… Continue reading Uncertain Benefits of Oral #Vancomycin for Prevention of Recurrent #Clostridioides difficile Infection
DunedinPACNI estimates the longitudinal Pace of #Aging from a single brain #image to track health and disease
To understand how aging affects functional decline and increases disease risk, it is necessary to develop measures of how fast a person is aging. Using data from the Dunedin Study, we introduce an accurate and reliable measure for the rate of longitudinal aging derived from cross-sectional brain magnetic resonance imaging, that is, the Dunedin Pace… Continue reading DunedinPACNI estimates the longitudinal Pace of #Aging from a single brain #image to track health and disease
#Mind #Wandering during Implicit #Learning Is Associated with Increased Periodic #EEG Activity and Improved Extraction of Hidden Probabilistic Patterns
Mind wandering, occupying 30–50% of our waking time, remains an enigmatic phenomenon in cognitive neuroscience. A large number of studies showed a negative association between mind wandering and attention-demanding (model-based) tasks in both natural settings and laboratory conditions. Mind wandering, however, does not seem to be detrimental for all cognitive domains and was observed to… Continue reading #Mind #Wandering during Implicit #Learning Is Associated with Increased Periodic #EEG Activity and Improved Extraction of Hidden Probabilistic Patterns
#Ambroxol as a #Treatment for #Parkinson Disease #DementiaA Randomized Clinical Trial
Importance Carrying a variation in the gene for β-glucocerebrosidase is a major risk factor for Parkinson disease dementia (PDD), and raising β-glucocerebrosidase levels lowers α-synuclein in cell and animals. Ambroxol is a chaperone for β-glucocerebrosidase, which increases the levels of β-glucocerebrosidase.Objective To examine the safety and tolerability of ambroxol in PDD, test the efficacy of… Continue reading #Ambroxol as a #Treatment for #Parkinson Disease #DementiaA Randomized Clinical Trial
The relationship between #polyunsaturated #fatty acids and #inflammation: evidence from cohort and Mendelian randomization analyses
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) are thought to have anti- and pro-inflammatory roles, respectively, and influence the risk of various chronic diseases. However, it is unclear whether these associations are causal.MethodsWe examined the associations of dietary polyunsaturated FAs with biomarkers of systemic inflammation: C-reactive protein (CRP), glycoprotein acetyls (GlycA), and interleukin… Continue reading The relationship between #polyunsaturated #fatty acids and #inflammation: evidence from cohort and Mendelian randomization analyses
Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant #Coffee and Age-Related #Macular Degeneration
Coffee is a popular beverage, and previous cohort studies suggest it may reduce the risk of age-related macular degeneration (AMD). However, confounding factors in these studies necessitate further exploration of causal relationships using advanced methods. We obtained data on coffee consumption from genome-wide association studies (GWAS) and the latest AMD-related GWAS summary data from the… Continue reading Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant #Coffee and Age-Related #Macular Degeneration
2 Medical News 