Existing evidence suggests links between brain and cardiovascular health. We investigated associations between cognitive performance and cardiovascular magnetic resonance (CMR) phenotypes in the UK Biobank, considering a range of potential confounders. Methods and resultsWe studied 29 763 participants with CMR and cognitive testing, specifically, fluid intelligence (FI, 13 verbal-numeric reasoning questions), and reaction time (RT, a… Continue reading Associations of #cognitive performance with #cardiovascular magnetic resonance phenotypes in the UK Biobank
#Antihypertensives and #Statin Therapy for Primary #Stroke Prevention
The HOPE-3 trial (Heart Outcomes Prevention Evaluation–3) found that antihypertensive therapy combined with a statin reduced first stroke among people at intermediate cardiovascular risk. We report secondary analyses of stroke outcomes by stroke subtype, predictors, treatment effects in key subgroups. Methods:Using a 2-by-2 factorial design, 12 705 participants from 21 countries with vascular risk factors… Continue reading #Antihypertensives and #Statin Therapy for Primary #Stroke Prevention
The associations between prenatal #cannabis use disorder and neonatal outcomes
Background and AimsCannabis use disorder (CUD) during pregnancy has increased dramatically in the United States (US). This study examined the associations between prenatal CUD and adverse neonatal outcomes and heterogeneities in the associations by mothers’ tobacco use status and race/ethnicity. DesignPopulation-based, retrospective cohort study. SettingCalifornia, USA. ParticipantsA total of 4.83 million mothers who delivered a… Continue reading The associations between prenatal #cannabis use disorder and neonatal outcomes
Clinical outcomes in a large registry of patients with major #depressive disorder treated with Transcranial #Magnetic Stimulation
Clinical outcomes were examined in the largest registry of patients treated for an episode of major depressive disorder. •The registry included more than more than 5,000 patients treated with TMS at more than 100 private practice sites. •Self-report and clinician ratings showed robust antidepressant effects, greater than those in the early studies of TMS. •Efficacy… Continue reading Clinical outcomes in a large registry of patients with major #depressive disorder treated with Transcranial #Magnetic Stimulation
Ultrasound renal #denervation for #hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial
Endovascular renal denervation reduces blood pressure in patients with mild-to-moderate hypertension, but its efficacy in patients with true resistant hypertension has not been shown. We aimed to assess the efficacy and safety of endovascular ultrasound renal denervation in patients with hypertension resistant to three or more antihypertensive medications. MethodsIn a randomised, international, multicentre, single-blind, sham-controlled… Continue reading Ultrasound renal #denervation for #hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial
Comparative Effectiveness of #Aspirin Dosing in #Cardiovascular Disease
The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy. METHODSUsing an open-label, pragmatic design, we randomly assigned patients with established atherosclerotic cardiovascular disease to a strategy of 81 mg or 325 mg… Continue reading Comparative Effectiveness of #Aspirin Dosing in #Cardiovascular Disease
The #overfitted brain: #Dreams evolved to assist generalization
Dreaming remains a mystery to neuroscience. While various hypotheses of why brains evolved nightly dreaming have been put forward, many of these are contradicted by the sparse, hallucinatory, and narrative nature of dreams, a nature that seems to lack any particular function. Recently, research on artificial neural networks has shown that during learning, such networks… Continue reading The #overfitted brain: #Dreams evolved to assist generalization
Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to a significant reduction in body weight gain due to enhanced… Continue reading Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
Mammalian enteral #ventilation ameliorates respiratory failure
Enteral ventilation (EVA) enabled systemic oxygenation in mammaliansEVA improved survival and behaviors in pre-clinical models of respiratory failureEVA yielded no major signs of complications in pre-clinical modelsEVA may serve as a transformative approach in respiratory failure patients Context and significanceThe SARS-CoV-2 pandemic has overwhelmed the clinical need for ventilators and artificial lungs, resulting in a… Continue reading Mammalian enteral #ventilation ameliorates respiratory failure
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