Enteral ventilation (EVA) enabled systemic oxygenation in mammaliansEVA improved survival and behaviors in pre-clinical models of respiratory failureEVA yielded no major signs of complications in pre-clinical modelsEVA may serve as a transformative approach in respiratory failure patients Context and significanceThe SARS-CoV-2 pandemic has overwhelmed the clinical need for ventilators and artificial lungs, resulting in a… Continue reading Mammalian enteral #ventilation ameliorates respiratory failure
#Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Calcium (Ca) is an essential nutrient that may play an important role in weight maintenance through its involvement in energy or lipid metabolism. However, little is known about the long-term associations of Ca intake with obesity risk. ObjectivesWe aimed to prospectively examine the association between cumulative Ca intake and the incidence of obesity among American… Continue reading #Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Tracking developmental differences in real-world social #attention across #adolescence, young adulthood and older #adulthood
Detecting and responding appropriately to social information in one’s environment is a vital part of everyday social interactions. Here, we report two preregistered experiments that examine how social attention develops across the lifespan, comparing adolescents (10–19 years old), young (20–40 years old) and older (60–80 years old) adults. In two real-world tasks, participants were immersed… Continue reading Tracking developmental differences in real-world social #attention across #adolescence, young adulthood and older #adulthood
#Smoking is associated with impaired verbal learning and #memory performance in women more than men
Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by exacerbating vascular disease risks. Sex disparities in VCID have been reported, however, few studies have assessed the sex-specific relationships between smoking and memory performance and… Continue reading #Smoking is associated with impaired verbal learning and #memory performance in women more than men
SARS-CoV-2 #Spike Protein Impairs #Endothelial Function via Downregulation of ACE 2
... SARS-CoV-2 infection induces EC inflammation, leading to endotheliitis.1,5 Because S protein decreased ACE2 level and impaired NO bioavailability, we examined whether S protein entry is indispensable for dysfunctional endothelium. As shown in Figure [F], i, the endothelium-dependent vasodilation induced by acetylcholine was impaired in pulmonary arteries isolated from Pseu-Spike-administered hamsters, whereas the endothelium-independent vasodilation… Continue reading SARS-CoV-2 #Spike Protein Impairs #Endothelial Function via Downregulation of ACE 2
Prospective Case-Control Study of #Cardiovascular Abnormalities 6 Months Following Mild #COVID-19 in Healthcare Workers
ObjectivesThe purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome coronavirus 2 infection.BackgroundConcern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. MethodsParticipants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology… Continue reading Prospective Case-Control Study of #Cardiovascular Abnormalities 6 Months Following Mild #COVID-19 in Healthcare Workers
#Cardiovascular symptoms affect the patterns of habitual #coffee consumption
Excessive coffee consumption can lead to unpleasant sensations such as tachycardia and heart palpitations. ObjectivesOur aim was to investigate if cardiovascular symptoms can lead to alterations in habitual patterns of coffee consumption. MethodsWe used information from up to 390,435 European ancestry participants in the UK Biobank, aged 39–73 y. Habitual coffee consumption was self-reported, and… Continue reading #Cardiovascular symptoms affect the patterns of habitual #coffee consumption
#Sarcopenia is independently associated with #parietal atrophy in older adults
Highlights•Sarcopenia was common in old adults living in a retirement community (46.1%). •Sarcopenia had moderate-severe global cortical, parietal and medial temporal atrophy. •Sarcopenia is significantly associated with parietal atrophy in older adults. •Age had a significant relationship with global cortical and medial temporal atrophy. AbstractIntroductionAs populations age, sarcopenia becomes a major health problem among adults… Continue reading #Sarcopenia is independently associated with #parietal atrophy in older adults
Colonization of the #Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
Protein conformational diseases are characterized by misfolding and toxic aggregation of metastable proteins, often culminating in neurodegeneration. Enteric bacteria influence the pathogenesis of neurodegenerative diseases; however, the complexity of the human microbiome hinders our understanding of how individual microbes influence these diseases. Disruption of host protein homeostasis, or proteostasis, affects the onset and progression of… Continue reading Colonization of the #Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
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