Extrasynaptic levels of dopamine in mouse cortex exhibit spontaneous impulses•Impulses are broadly distributed in amplitude and time, with a rate of about 0.01/s•Feedback was used to train mice to volitionally control their spontaneous impulses•Mice learned to reliably modulate dopamine impulses in order to receive a reward SummaryIn their pioneering study on dopamine release, Romo and …

Continue reading Reinforcement learning links spontaneous cortical #dopamine impulses to reward