Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin… Continue reading Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
Category: Neurology
#Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy.. ..The rate of decline in 3MS was significantly… Continue reading #Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
Lifetime perspective on #alcohol and #brain health
Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65… Continue reading Lifetime perspective on #alcohol and #brain health
Acute social #isolation evokes midbrain craving responses similar to #hunger
When people are forced to be isolated from each other, do they crave social interactions? To address this question, we used functional magnetic resonance imaging to measure neural responses evoked by food and social cues after participants (n = 40) experienced 10 h of mandated fasting or total social isolation. After isolation, people felt lonely and craved social… Continue reading Acute social #isolation evokes midbrain craving responses similar to #hunger
Cognitive impairment and #sedentary behavior predict health-related attrition in a prospective longitudinal #Parkinson’s disease study
In Parkinson's disease (PD), the high burden of motor and non-motor symptoms, such as cognitive impairment or falls, is associated with rapid disease progression and mortality. This is often reflected by an increased drop-out rate of PD patients in longitudinal studies. Active physical behavior can impact the disease course beneficially and has an overall positive… Continue reading Cognitive impairment and #sedentary behavior predict health-related attrition in a prospective longitudinal #Parkinson’s disease study
Partial and Total #Sleep Deprivation Interferes with Neural Correlates of Consolidation of #Fear Extinction #Memory
We assessed the impact of total and partial sleep loss on neural correlates of fear conditioning and extinction learning and recall in healthy young adults. Methods Participants (56.3% female, age 24.8±3.4) were randomized to a night of normal sleep (NS, n=48), sleep restriction (SR, n=53), or sleep deprivation (SD, n=53). All completed fear conditioning and… Continue reading Partial and Total #Sleep Deprivation Interferes with Neural Correlates of Consolidation of #Fear Extinction #Memory
#Dementia and the risk of death in elderly patients with #COVID‐19 infection: Systematic review and meta‐analysis
The COVID‐19 infection represents a global public health emergency worldwide. Several risk factors have been associated with a poor prognosis among COVID‐19 patients. We aimed to perform a systemic review and meta‐analysis to evaluate the mortality risk in elderly patients with dementia and COVID‐19 infection.. ..A total of 233 articles were retrieved; 158 were excluded… Continue reading #Dementia and the risk of death in elderly patients with #COVID‐19 infection: Systematic review and meta‐analysis
Polypill with or without Aspirin in Persons without #Cardiovascular Disease
..Using a 2-by-2-by-2 factorial design, we randomly assigned participants without cardiovascular disease who had an elevated INTERHEART Risk Score to receive a polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or placebo daily, aspirin (75 mg) or placebo daily, and vitamin D or placebo… Continue reading Polypill with or without Aspirin in Persons without #Cardiovascular Disease
#Ticagrelor Added to #Aspirin in Acute Ischemic #Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
Reduction of subsequent disabling stroke is the main goal of preventive treatment in the acute setting after transient ischemic attack (TIA) or minor ischemic stroke.. ..Ticagrelor (180-mg loading dose on day 1 followed by 90 mg twice daily for days 2-30) or placebo within 24 hours of symptom onset. All patients received aspirin, 300 to… Continue reading #Ticagrelor Added to #Aspirin in Acute Ischemic #Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
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