Animals coexist in commensal, pathogenic or mutualistic relationships with complex communities of diverse organisms, including microorganisms. Some bacteria produce bioactive neurotransmitters that have previously been proposed to modulate nervous system activity and behaviours of their hosts. However, the mechanistic basis of this microbiota–brain signalling and its physiological relevance are largely unknown. Here we show that… Continue reading A neurotransmitter produced by #gut bacteria modulates host sensory #behaviour
Category: Neurology
Relationship between afternoon #napping and #cognitive function in the ageing Chinese population
Several studies have shown that afternoon napping promotes cognitive function in the elderly; on the other hand, some studies have shown opposite results. This current study further examined the relationship between afternoon napping and cognitive function in the ageing Chinese population. Methods A total of 2214 elderly were included (napping group: n=1534; non-napping group: n=680).… Continue reading Relationship between afternoon #napping and #cognitive function in the ageing Chinese population
The effects of #alcohol and #cannabis use on the cortical thickness of #cognitive control and salience brain networks in emerging adulthood: a cotwin control study
Background Impairments in inhibitory control and its underlying brain networks (control/salience areas) are associated with substance misuse. Research often assumes a causal substance exposure effect on brain structure. This assumption remains largely untested and other factors (e.g., familial risk) may confound exposure effects. We leveraged a genetically-informative sample of 24-year-old twins and a quasi-experimental cotwin… Continue reading The effects of #alcohol and #cannabis use on the cortical thickness of #cognitive control and salience brain networks in emerging adulthood: a cotwin control study
State-dependent responses to intracranial brain stimulation in a patient with #depression
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in… Continue reading State-dependent responses to intracranial brain stimulation in a patient with #depression
6-month consequences of #COVID-19 in patients discharged from hospital: a cohort study
The long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.. ..In total, 1733 of 2469 discharged patients with COVID-19 were enrolled after 736 were… Continue reading 6-month consequences of #COVID-19 in patients discharged from hospital: a cohort study
Clinical Outcomes Associated With Left #Atrial Appendage Occlusion Versus Direct Oral #Anticoagulation in Atrial #Fibrillation
This study sought to investigate clinical outcomes associated with left atrial appendage occlusion (LAAO) versus direct oral anticoagulants (DOACs) in patients with high-risk atrial fibrillation (AF).. ..Patients with AF enrolled in the Amulet Observational Registry (n = 1,088) who had successful LAAO with the Amplatzer Amulet device (n = 1,078) were compared with a propensity… Continue reading Clinical Outcomes Associated With Left #Atrial Appendage Occlusion Versus Direct Oral #Anticoagulation in Atrial #Fibrillation
#Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
Highlights •We investigated whether recent and/or remote depression was associated with increased risk of Alzheimer's Dementia (AD) and whether this risk differed between men and women. •Recent depression was independently associated with increased risk of incident AD while remote depression was not. Recent depression was predictive of AD development in females, but not in males,… Continue reading #Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
Five‐Year Risk of Acute #Myocardial Infarction After Acute Ischemic #Stroke in Korea
The long‐term incidence of acute myocardial infarction (AMI) in patients with acute ischemic stroke (AIS) has not been well defined in large cohort studies of various race‐ethnic groups. A prospective cohort of patients with AIS who were registered in a multicenter nationwide stroke registry (CRCS‐K [Clinical Research Collaboration for Stroke in Korea] registry) was followed… Continue reading Five‐Year Risk of Acute #Myocardial Infarction After Acute Ischemic #Stroke in Korea
BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury
Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB). One approach to overcoming this challenge involves treatment administration while BBB is transiently breached after injury. However, it offers a limited window for therapeutic intervention and is applicable to only… Continue reading BBB pathophysiology–independent delivery of siRNA in traumatic #brain injury
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