Very few studies have explored the patterns of cardiovascular health (CVH) metrics in midlife and late life in relation to risk of dementia. We examined the associations of composite CVH metrics from midlife to late life with risk of incident dementia. This cohort study included 1,449 participants from the Finnish Cardiovascular Risk Factors, Aging, and… Continue reading #Cardiovascular health metrics from mid- to late-life and risk of #dementia: A population-based cohort study in Finland
Category: Neurology
Prefrontal– #amygdala circuits in #social decision-making
An increasing amount of research effort is being directed toward investigating the neural bases of social cognition from a systems neuroscience perspective. Evidence from multiple animal species is beginning to provide a mechanistic understanding of the substrates of social behaviors at multiple levels of neurobiology, ranging from those underlying high-level social constructs in humans and… Continue reading Prefrontal– #amygdala circuits in #social decision-making
Trial of #Dexamethasone for Chronic Subdural #Hematoma
Chronic subdural hematoma is a common neurologic disorder that is especially prevalent among older people. The effect of dexamethasone on outcomes in patients with chronic subdural hematoma has not been well studied.. ..From August 2015 through November 2019, a total of 748 patients were included in the trial after randomization — 375 were assigned to… Continue reading Trial of #Dexamethasone for Chronic Subdural #Hematoma
#Apathy in presymptomatic genetic frontotemporal #dementia predicts cognitive decline and is driven by structural brain changes
Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy.. ..Results Apathy severity increased over time in presymptomatic carriers, but not in non‐carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but… Continue reading #Apathy in presymptomatic genetic frontotemporal #dementia predicts cognitive decline and is driven by structural brain changes
Changes in Body #Mass Index Are Related to Faster #Cognitive Decline Among African American Older Adults
The purpose of this study was to: (1) examine relationships between body mass index (BMI) stability and cognitive decline in older African Americans; and (2) investigate differences in the relationships between women and men.. ..Participants (n = 671; mean age = 73.5 years; standard deviation = 6.2 years) were included in the present analysis if they were… Continue reading Changes in Body #Mass Index Are Related to Faster #Cognitive Decline Among African American Older Adults
Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin… Continue reading Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
#Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy.. ..The rate of decline in 3MS was significantly… Continue reading #Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
Lifetime perspective on #alcohol and #brain health
Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65… Continue reading Lifetime perspective on #alcohol and #brain health
Acute social #isolation evokes midbrain craving responses similar to #hunger
When people are forced to be isolated from each other, do they crave social interactions? To address this question, we used functional magnetic resonance imaging to measure neural responses evoked by food and social cues after participants (n = 40) experienced 10 h of mandated fasting or total social isolation. After isolation, people felt lonely and craved social… Continue reading Acute social #isolation evokes midbrain craving responses similar to #hunger
2 Medical News 