BackgroundGlucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD). However, the probability of low semaglutide doses, an agonist with higher potency and affinity for GLP-1R, to attenuate alcohol-related responses in rodents and the underlying neuronal mechanisms is unknown.MethodsIn the intermittent access model,… Continue reading Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats
Category: Endocrinology
Impact of a Low-Carbohydrate Compared with Low-Fat Breakfast on Blood Glucose Control in Type 2 Diabetes: A Randomized Trial
BackgroundIn type 2 diabetes (T2D), consuming carbohydrates results in a rapid and large increase in blood glucose, particularly in the morning when glucose intolerance is highest.ObjectivesWe investigated if a low-carbohydrate (LC) breakfast (∼465 kcal: 25 g protein, 8 g carbohydrates, and 37 g fat) could improve glucose control in people with T2D when compared with a low-fat control (CTL) breakfast (∼450… Continue reading Impact of a Low-Carbohydrate Compared with Low-Fat Breakfast on Blood Glucose Control in Type 2 Diabetes: A Randomized Trial
Accelerometer-measured intensity-specific physical activity, genetic risk and incident type 2 diabetes: a prospective cohort study
Objective Although 30 min/day of moderate-intensity physical activity is suggested for preventing type 2 diabetes (T2D), the current recommendations exclusively rely on self-reports and rarely consider the genetic risk. We examined the prospective dose-response relationships between total/intensity-specific physical activity and incident T2D accounting for and stratified by different levels of genetic risk.Methods This prospective cohort study was… Continue reading Accelerometer-measured intensity-specific physical activity, genetic risk and incident type 2 diabetes: a prospective cohort study
Analysis of Body Mass Index in Early and Middle Adulthood and Estimated Risk of Gastrointestinal Cancer
Importance In a population with significantly increasing rates of individuals with overweight or obesity, understanding the association of obesity with long-term disease risk, such as cancer, is necessary to improve public health.Objective To investigate the association between body mass index (BMI) and gastrointestinal (GI) cancer risk (colorectal cancer [CRC] and noncolorectal GI cancer) in the Prostate, Lung,… Continue reading Analysis of Body Mass Index in Early and Middle Adulthood and Estimated Risk of Gastrointestinal Cancer
Testicular volume in 268 children and adolescents followed-up for childhood obesity—a retrospective cross-sectional study
AbstractContextPrevalence of obesity in childhood has increased over the past few decades. The impact of obesity and of obesity-related metabolic disorders on testicular growth is unknown.ObjectiveTo evaluate the impact of obesity, hyperinsulinemia, and insulin resistance on testicular volume (TV) in pre-pubertal (<9 years), peri-pubertal (9-14 years), and post-pubertal (14-16 years) periods.MethodsWe collected data on TV,… Continue reading Testicular volume in 268 children and adolescents followed-up for childhood obesity—a retrospective cross-sectional study
Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
Highlights•PCOS-sons are often obese and have dyslipidemia•miRNAs altered in the serum of PCOS-sons and women with PCOS targets PCOS-risk genes•Small RNAs present in sperm imply transgenerational transmission of phenotype in mice•Shared miRNAs between mouse sperm of F1–F3 generations and human serum are revealedSummaryThe transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female progeny are being… Continue reading Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
Lifestyle mediators of associations among siestas, obesity, and metabolic health
ObjectiveThe aim of this study was to determine the association between siestas/no siestas and obesity, considering siesta duration (long: >30 minutes, short: ≤30 minutes), and test whether siesta traits and/or lifestyle factors mediate the association of siestas with obesity and metabolic syndrome (MetS).MethodsThis was a cross-sectional study of 3275 adults from a Mediterranean population (the Obesity, Nutrigenetics,… Continue reading Lifestyle mediators of associations among siestas, obesity, and metabolic health
Development and Validation of a Prediction Model for Future Estimated Glomerular Filtration Rate in People With Type 2 Diabetes and Chronic Kidney Disease
Type 2 diabetes increases the risk of progressive diabetic kidney disease, but reliable prediction tools that can be used in clinical practice and aid in patients’ understanding of disease progression are currently lacking.Objective To develop and externally validate a model to predict future trajectories in estimated glomerular filtration rate (eGFR) in adults with type 2… Continue reading Development and Validation of a Prediction Model for Future Estimated Glomerular Filtration Rate in People With Type 2 Diabetes and Chronic Kidney Disease
Development of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a Sulfonylurea
Metformin may have a protective association against developing osteoarthritis (OA), but robust epidemiological data are lacking.Objective To determine the risk of OA and joint replacement in individuals with type 2 diabetes treated with metformin compared with a sulfonylurea.Design, Setting, and Participants This retrospective cohort study used claims data from the Optum deidentified Clinformatics Data Mart… Continue reading Development of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a Sulfonylurea
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