The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation. Design We investigated the relation between 173… Continue reading Long-term #dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut #microbiome
Category: Diet
Long-term body mass index changes in #overweight and #obese adults and the risk of heart failure, #cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK
Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantified. MethodsThis population-based cohort study used routine UK primary care electronic health data linked to secondary care and… Continue reading Long-term body mass index changes in #overweight and #obese adults and the risk of heart failure, #cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK
Association of #sugary drink consumption with all-cause and cause-specific #mortality: the Japan Public Health Center-based Prospective Study
Highlights•We assessed the association between sugary drinks and mortality in Japan. •Sugary drink consumption was positively associated with all-cause mortality. •Sugary drinks increased risk of death from circulatory system diseases. AbstractBackgroundFew epidemiologic studies have assessed the associations of sugary drink consumption with mortality outcomes among Asian populations. MethodsThis study included 70,486 participants in the Japan… Continue reading Association of #sugary drink consumption with all-cause and cause-specific #mortality: the Japan Public Health Center-based Prospective Study
Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at… Continue reading Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials
A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis. Methods For this systematic review and meta-analysis,… Continue reading Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials
Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites
Probiotic milk-fermented microorganism mixtures (e.g., yogurt, kefir) are perceived as contributing to human health, and possibly capable of protecting against bacterial infections. Co-existence of probiotic microorganisms are likely maintained via complex biomolecular mechanisms, secreted metabolites mediating cell-cell communication, and other yet-unknown biochemical pathways. In particular, deciphering molecular mechanisms by which probiotic microorganisms inhibit proliferation of… Continue reading Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites
#Metabolic syndrome and #gastric cancer risk: a systematic review and meta-analysis
Gastric cancer (GC) is the fifth diagnosed cancer worldwide and the third leading cause of death for cancer. Recent reports suggest that metabolic syndrome (MetS) has a role in etiology, progression or prognosis on GC. The aim of this study is to systematically review the evidence on the association between MetS and GC risk and… Continue reading #Metabolic syndrome and #gastric cancer risk: a systematic review and meta-analysis
Effect of Early High-Dose Vitamin #D3 Repletion on Cognitive Outcomes in Critically Ill Adults
Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition. Research Question Does a single high-dose (540,000 IU) enteral treatment of vitamin D3 given shortly after hospital admission in vitamin D deficient, critically-ill patients improve long-term global cognition or executive function? Study Design and Methods This study evaluated long-term… Continue reading Effect of Early High-Dose Vitamin #D3 Repletion on Cognitive Outcomes in Critically Ill Adults
#Obesity and Responsiveness to #Food Marketing Before and After #Bariatric Surgery
Although food marketing is often accused of increasing population obesity, the relationship between individual responsiveness to marketing and obesity has yet to be established: Are people with obesity more responsive to food marketing and, if so, is it a stable trait or can it be reversed by bariatric surgery? We studied the responses to three… Continue reading #Obesity and Responsiveness to #Food Marketing Before and After #Bariatric Surgery
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