A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to… Continue reading High- #fat diet–induced #colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
Category: Diet
#Plant‐Centered Diet and Risk of Incident #Cardiovascular Disease During Young to Middle Adulthood
The association between diets that focus on plant foods and restrict animal products and cardiovascular disease (CVD) is inconclusive. We investigated whether cumulative intake of a plant‐centered diet and shifting toward such a diet are associated with incident CVD. Methods and ResultsParticipants were 4946 adults in the CARDIA (Coronary Artery Risk Development in Young Adults)… Continue reading #Plant‐Centered Diet and Risk of Incident #Cardiovascular Disease During Young to Middle Adulthood
Ultra-processed #foods consumption and #diet quality of European children, adolescents and adults: results from the I.Family study
Energy intake from Ultra Processed Foods (UPFs) represents almost half of the daily energy intake within our study population, and this trend decrease progressively with age with no differences by cultural and socio-economic status.•Considering the quintiles of the dietary share of UPFs, energy intake increases across the quintiles, and diet quality is significantly lower in… Continue reading Ultra-processed #foods consumption and #diet quality of European children, adolescents and adults: results from the I.Family study
Association of #alcohol consumption with morbidity and mortality in patients with #cardiovascular disease: original data and meta-analysis of 48,423 men and women
Light-to-moderate alcohol consumption has been reported to be cardio-protective among apparently healthy individuals; however, it is unclear whether this association is also present in those with disease. To examine the association between alcohol consumption and prognosis in individuals with pre-existing cardiovascular disease (CVD), we conducted a series of meta-analyses of new findings from three large-scale… Continue reading Association of #alcohol consumption with morbidity and mortality in patients with #cardiovascular disease: original data and meta-analysis of 48,423 men and women
#Meal composition during an ad libitum buffet meal and longitudinal predictions of #weight and percent body fat change: The role of hyper-palatable, energy dense, and ultra-processed foods
Foods that increase obesity risk are ubiquitous in the US food environment. Such foods may be the target of hedonic eating, which may facilitate weight gain and lead to obesity. The study tested whether meal composition during an ad libitum buffet meal was associated with 1-year weight and percent body fat changes among healthy younger… Continue reading #Meal composition during an ad libitum buffet meal and longitudinal predictions of #weight and percent body fat change: The role of hyper-palatable, energy dense, and ultra-processed foods
Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort
RBC long-chain omega-3 (n–3) fatty acid (FA) percentages (of total fatty acids) are associated with lower risk for total mortality, but it is unknown if a suite of FAs could improve risk prediction. ObjectivesThe objective of this study was to compare a combination of RBC FA levels with standard risk factors for cardiovascular disease (CVD)… Continue reading Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort
Long-term Dietary #Flavonoid Intake and Subjective #Cognitive Decline in US Men and Women
To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD). Methods: We followed 49,493 women from the Nurses’ Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids,… Continue reading Long-term Dietary #Flavonoid Intake and Subjective #Cognitive Decline in US Men and Women
Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock
Distribution of dietary protein across meals influences muscle hypertrophy•BCAAs are involved in hypertrophic effects of protein feeding distribution•Hypertrophic effects of protein feeding distribution require the muscle clock•Breakfast protein intake is correlated with skeletal muscle functions in older women SummaryThe meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the… Continue reading Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock
Associations of #overweight and #obesity with drug-resistant #epilepsy
The group with epilepsy included in this study had a lower proportion of individuals with overweight and obesity than the general population (23.1% versus 42%) in 2015. However, the proportion of patients with obesity in the groups with DRE was significantly higher than that in the general population (17.9% versus 7.1%).•The J-shaped relationship between BMI… Continue reading Associations of #overweight and #obesity with drug-resistant #epilepsy
