Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of CAD, we performed comprehensive clinical and multi-omic profiling, including serum metabolomics and gut microbiome data, for 199 patients with acute coronary syndrome (ACS) recruited from two major Israeli hospitals, and validated… Continue reading Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease
Author: aledopress
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Ipertensione dopo vaccinazione anti-COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread across the world, killing more than 4 million individuals globally, with 240 million individuals being confirmed by laboratory tests. Among different therapeutic strategies to prevent SARS-CoV-2 infection, vaccines are the most promising approach for curbing the pandemic. They elicit an immune neutralizing response and thus offer… Continue reading Ipertensione dopo vaccinazione anti-COVID-19
Efficacy of botulinum toxin A injection in the treatment of androgenic alopecia: A Comparative Controlled Study
IntroductionScalp injection with mesotherapy (LC cell hair essence) helps in anchoring hair follicles and might have good therapeutic efficacy and lower side effects than Botox in the treatment of androgenetic alopecia (AGA). ObjectiveTo assess the trichoscopy and the clinical therapeutic response of LC hair essence serum injection vs. botulinum toxin (A) injection in the treatment… Continue reading Efficacy of botulinum toxin A injection in the treatment of androgenic alopecia: A Comparative Controlled Study
Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without
Highlights•Minimal levels of SARS-CoV-2 spike protein can cause cell fusion •Spike protein displayed on virus-like particles induces fusion from without •Particle-cell fusion is more sensitive toward neutralization than cell-cell fusion •Highly sensitive and scalable membrane fusion assays are applicable at BSL-1 Cell entry of the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated… Continue reading Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without
Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome
Some missense gain-of-function mutations in the CACNA1C gene, encoding calcium channel CaV1.2, cause a life-threatening form of long QT syndrome (LQTS) named Timothy syndrome with currently no clinically effective therapeutics. Here we report that pharmacological targeting of sigma non-opioid intracellular receptor 1 (SIGMAR1) can restore electrophysiological function in induced pluripotent stem cell (iPSC)-derived cardiomyocytes generated… Continue reading Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome
Fourth Dose COVID mRNA Vaccines’ Immunogenicity & Efficacy Against Omicron VOC
AbstractBACKGROUND Following the emergence of the Omicron variant of concern, we investigated immunogenicity, efficacy and safety of BNT162b2 or mRNA1273 fourth dose in an open-label, clinical intervention trial. METHODS Primary end-points were safety and immunogenicity and secondary end-points were vaccine efficacy in preventing SARS-CoV-2 infections and COVID-19 symptomatic disease. The two intervention arms were compared… Continue reading Fourth Dose COVID mRNA Vaccines’ Immunogenicity & Efficacy Against Omicron VOC
Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature
BackgroundTogether with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due… Continue reading Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature
Health-care workers recovered from natural SARS-CoV-2 infection should be exempt frommandatory vaccination edicts
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Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline
Background and Objective: Loneliness is common and its prevalence is rising. The relationship of loneliness with subsequent dementia and the early preclinical course of Alzheimer disease and related dementia (ADRD) remains unclear. Thus, the primary objective of this study was to determine the association of loneliness with 10-year all-cause dementia risk and early cognitive and… Continue reading Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline
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