Renal dysfunction is one of the most critical risk factors for developing heart failure (HF). However, the association between repeated measures of renal function and incident HF remains unclear. Therefore, this study investigated the longitudinal trajectories of urinary albumin excretion (UAE) and serum creatinine and their association with new-onset HF and all-cause mortality.Methods and resultsUsing… Continue reading Trajectories of #renal biomarkers and new-onset #heart failure in the general population: Findings from the PREVEND study
Author: aledopress
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#Depression, #anxiety, and the risk of #cancer: An individual participant data meta-analysis
Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related… Continue reading #Depression, #anxiety, and the risk of #cancer: An individual participant data meta-analysis
Prospective Associations of Different Combinations of #Aerobic and #Muscle-Strengthening Activity With All-Cause, #Cardiovascular, and Cancer Mortality
Studies examining the associations of different combinations of intensity-specific aerobic and muscle strengthening activity (MSA) with all-cause and cause-specific mortality are scarce; the few available estimates are disparate.Objective To examine the prospective associations of different combinations of moderate aerobic physical activity (MPA), vigorous aerobic physical activity (VPA), and MSA with all-cause, cardiovascular (CVD), and cancer mortality.Design,… Continue reading Prospective Associations of Different Combinations of #Aerobic and #Muscle-Strengthening Activity With All-Cause, #Cardiovascular, and Cancer Mortality
BETTER THAN WE THINK: IS THE TREATMENT OF #DEPRESSED PATIENTS MORE EFFECTIVE THAN WE THINK?
Most studies of depression treatment rely on measures of symptom severity to evaluate outcome. We hypothesized that many patients would consider themselves to have benefitted significantly from treatment despite not being considered a responder according to a measure of depression symptom severity (ie, 50% reduction in symptom score).METHODS: In our study, 854 patients with major depressive… Continue reading BETTER THAN WE THINK: IS THE TREATMENT OF #DEPRESSED PATIENTS MORE EFFECTIVE THAN WE THINK?
The #fructose survival hypothesis for #obesity
The fructose survival hypothesis proposes that obesity and metabolic disorders may have developed from over-stimulation of an evolutionary-based biologic response (survival switch) that aims to protect animals in advance of crisis. The response is characterized by hunger, thirst, foraging, weight gain, fat accumulation, insulin resistance, systemic inflammation and increased blood pressure. The process is initiated by the… Continue reading The #fructose survival hypothesis for #obesity
Cumulative Use of #Proton Pump Inhibitors and Risk of #Dementia: The Atherosclerosis Risk in Communities Study
Studies on the association between proton pump inhibitor (PPI) use and dementia report mixed results and do not examine the impact of cumulative PPI use. We evaluated the associations between current and cumulative PPI use and risk of incident dementia in the Atherosclerosis Risk in Communities (ARIC) Study.Methods. These analyses used participants from a community-based cohort… Continue reading Cumulative Use of #Proton Pump Inhibitors and Risk of #Dementia: The Atherosclerosis Risk in Communities Study
High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
Highlights•Studies have shown that high PTH was associated with NAFLD/NASH, although the results from existing studies are inconsistent.•Using systematic review, 10 and 4 studies reported the association of PTH with NAFLD and NASH, respectively.•The meta-analysis suggested that high PTH can be a marker of NAFLD.•The meta-analysis also revealed that high PTH tended to be associated… Continue reading High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
Association between added #sugars and kidney #stones in U.S. adults: data from National Health and Nutrition Examination Survey 2007–2018
Added sugar is associated with a variety of adverse health outcomes, but its association with kidney stones is unclear. This study was to determine whether added sugar is associated with kidney stones.Materials and methods: This nationally representative study used National Health and Nutrition Examination Survey (NHANES) datasets from 2007 to 2018 for analysis. People aged ≥20 years… Continue reading Association between added #sugars and kidney #stones in U.S. adults: data from National Health and Nutrition Examination Survey 2007–2018
Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
The risk of cardiovascular disease is increased among persons with human immunodeficiency virus (HIV) infection, so data regarding primary prevention strategies in this population are needed.METHODSIn this phase 3 trial, we randomly assigned 7769 participants with HIV infection with a low-to-moderate risk of cardiovascular disease who were receiving antiretroviral therapy to receive daily pitavastatin calcium… Continue reading Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
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