While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per… Continue reading Individual and additive effects of vitamin #D, #omega-3 and #exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Tag: omega-3
Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank
AbstractPrevious epidemiological studies on the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega-3 and omega-6 PUFAs with the incidence of overall and 19 site-specific cancers in a large prospective cohort. 253,138 eligible UK Biobank participants were included in our study. With a mean follow-up… Continue reading Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank
ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) have more brain white matter lesions (WMLs), an association suggesting that small-vessel ischemic disease, a major contributor to the development of dementia, including Alzheimer disease, may be preventable through ω-3 treatment.Objective To… Continue reading ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
#Omega-3 supplementation reduces aggressive #behavior: A meta-analytic review of randomized controlled trials
AbstractThere is increasing interest in the use of omega-3 supplements to reduce aggressive behavior. This meta-analysis summarizes findings from 29 RCTs (randomized controlled trials) on omega-3 supplementation to reduce aggression, yielding 35 independent samples with a total of 3918 participants. Three analyses were conducted where the unit of analysis was independent samples, independent studies, and… Continue reading #Omega-3 supplementation reduces aggressive #behavior: A meta-analytic review of randomized controlled trials
Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive. Herein, we used multi-omic network analysis that unveiled critical molecular pathways involved in ω3 PUFA effects in a preclinical mouse model of western diet induced… Continue reading Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
Vitamin D and Marine n-3 Fatty Acid Supplementation and Prevention of Autoimmune Disease in the VITAL Randomized Controlled Trial
In observational studies, vitamin D has been inconsistently associated with reduced risk of several autoimmune diseases, and a large randomized, controlled trial has been lacking. Dietary marine-derived long-chain omega-3 (n−3) fatty acids decrease systemic inflammation and ameliorate symptoms in some autoimmune diseases, but no trials have tested whether supplementation lowers risk of developing autoimmune disease.… Continue reading Vitamin D and Marine n-3 Fatty Acid Supplementation and Prevention of Autoimmune Disease in the VITAL Randomized Controlled Trial
Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates
•A processed-foods diet (PD) impaired learning and memory in aged male rats. •PD increased inflammatory genes in the hippocampus and amygdala of aged rats. •DHA supplementation prevented memory deficits in PD-fed aged rats. •DHA supplementation ameliorated increases in inflammatory gene expression. •PD consumption led to increased weight gain in young and aged rats. AbstractThe consumption… Continue reading Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates
Effect of Long-Term Marine #Omega-3 Fatty Acids Supplementation on the Risk of Atrial #Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Some, but not all, large-scale randomized controlled trials (RCTs) investigating the effects of marine omega-3 fatty acids supplementation on cardiovascular outcomes have reported increased risks of atrial fibrillation (AF). The potential reasons for disparate findings may be dose related. Methods: The MEDLINE and Embase databases were searched for articles and abstracts published between January 1,… Continue reading Effect of Long-Term Marine #Omega-3 Fatty Acids Supplementation on the Risk of Atrial #Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort
RBC long-chain omega-3 (n–3) fatty acid (FA) percentages (of total fatty acids) are associated with lower risk for total mortality, but it is unknown if a suite of FAs could improve risk prediction. ObjectivesThe objective of this study was to compare a combination of RBC FA levels with standard risk factors for cardiovascular disease (CVD)… Continue reading Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort
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