The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic… Continue reading Role and Mechanism of Gut #Microbiota in Human #Disease
Tag: NAFLD
#NONALCOHOLIC FATTY LIVER DISEASE-RELATED RISK OF #CARDIOVASCULAR DISEASE AND OTHER CARDIAC COMPLICATIONS
Nonalcoholic fatty liver disease (NAFLD) affects approximately ~25% of the global adult population. The aim of this narrative review is to describe the associations between NAFLD and cardiovascular disease (CVD), arrhythmias, cardiac conduction defects, myocardial remodelling and heart failure. We also discuss the potential mechanisms that mediate or attenuate the strength of these associations, and… Continue reading #NONALCOHOLIC FATTY LIVER DISEASE-RELATED RISK OF #CARDIOVASCULAR DISEASE AND OTHER CARDIAC COMPLICATIONS
Effects of #Tamoxifen vs. Toremifene on #fatty liver development and lipid profiles in #breast Cancer
Tamoxifen (TAM) and Toremifene (TOR), two kinds of selective estrogen receptor modulators (SERMs), have equal efficacy in breast cancer patients. However, TAM has been proved to affect serum lipid profiles and cause fatty liver disease. The study aimed to compare the effects of TAM and TOR on fatty liver development and lipid profiles. MethodsThis study… Continue reading Effects of #Tamoxifen vs. Toremifene on #fatty liver development and lipid profiles in #breast Cancer
Incidence of #liver-related morbidity and mortality in a population cohort of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) increases morbidity and mortality. However, patients in biopsy-based cohorts are highly selected and the absolute risks of liver- and non-liver outcomes in NAFLD in population remains undefined. We analyzed both liver-related and non-liver-related outcomes in Finnish population cohorts of NAFLD. MethodsWe included 10993 individuals (6707 men, mean age 53.3±12.6 years)… Continue reading Incidence of #liver-related morbidity and mortality in a population cohort of non-alcoholic fatty liver disease
Intact Fasting #Insulin Identifies Nonalcoholic Fatty #Liver Disease in Patients Without Diabetes
Patients with nonalcoholic fatty liver disease (NAFLD) are characterized by insulin resistance and hyperinsulinism. However, insulin resistance measurements have not been shown to be good diagnostic tools to predict NAFLD in prior studies. ObjectiveWe aimed to assess a newly validated method to measure intact molecules of insulin by mass spectrometry to predict NAFLD. MethodsPatients underwent… Continue reading Intact Fasting #Insulin Identifies Nonalcoholic Fatty #Liver Disease in Patients Without Diabetes
#Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis
Statin liver safety in non-alcoholic fatty liver disease (NAFLD) patients is not well defined. We analysed differences in liver function tests, including alanine transaminase aminotransferase (ALT), aspartate transaminase (AST), and gamma-glutamyl transpeptidase (GGT) in NAFLD patients treated or not with statins. MethodsWe performed a systematic review of MEDLINE via PubMed and EMBASE databases and metanalysis… Continue reading #Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis
Prevalence of increased #transaminases and its association with sex, age, and #metabolic parameters in children and adolescents wit7h obesity – a nationwide cross-sectional cohort study
Childhood obesity increases the risk of non-alcoholic fatty liver disease marked by elevated alanine aminotransferase (ALT). This study investigated the prevalence of increased ALT in children and adolescents with obesity, and its associations with sex, age, degree of obesity, and metabolic parameters. MethodsIndividuals between 5 and 17.99 years of age enrolled in the Swedish Childhood Obesity… Continue reading Prevalence of increased #transaminases and its association with sex, age, and #metabolic parameters in children and adolescents wit7h obesity – a nationwide cross-sectional cohort study
Opportunistic Screening of Patients for Hepatic #Steatosis: Clinical Follow-Up and Diagnostic Yield
Hepatic steatosis is a common incidental finding on abdominal imaging that is not always reported or recognized as having clinical significance. Because of its association with liver disease, cirrhosis, and diabetes, the aim of this study was to bring attention to this finding and provide clinical guidance to referring clinicians by inserting standardized text into… Continue reading Opportunistic Screening of Patients for Hepatic #Steatosis: Clinical Follow-Up and Diagnostic Yield
XCR1+ type 1 conventional #dendritic cells drive liver pathology in non-alcoholic #steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH, yet the cellular and molecular mechanisms of immune dysregulation in this disease are poorly understood. Here, using single-cell transcriptomic analysis,… Continue reading XCR1+ type 1 conventional #dendritic cells drive liver pathology in non-alcoholic #steatohepatitis
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