Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis

Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age. It is associated with dyslipidaemia and elevated plasma C-reactive protein (CRP), which increase the risks of cardiovascular disease (CVD). ObjectiveTo review the existing evidence on the effects of different pharmacological interventions on lipid profiles and CRP of women with PCOS. Data SourcesWe …

Continue reading Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis

Computational drug repositioning of #atorvastatin for ulcerative #colitis

Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatment and disease maintenance. We hypothesized that a multi-cohort analysis of independent cohorts representing real-world heterogeneity of UC would identify a robust transcriptomic signature to improve identification of FDA-approved drugs that can be repurposed to treat patients with UC. Materials …

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#Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis

Statin liver safety in non-alcoholic fatty liver disease (NAFLD) patients is not well defined. We analysed differences in liver function tests, including alanine transaminase aminotransferase (ALT), aspartate transaminase (AST), and gamma-glutamyl transpeptidase (GGT) in NAFLD patients treated or not with statins. MethodsWe performed a systematic review of MEDLINE via PubMed and EMBASE databases and metanalysis …

Continue reading #Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis

Atorvastatin in combination with conventional antimicrobial treatment of #Helicobacter pylori eradication: A randomized controlled clinical trial

..Considering the antiโ€inflammatory and antibacterial effect of atorvastatin, the present study aimed at adding this agent to a fourโ€drug regimen in order to eradicate H. pylori. In the current study, 110 patients in the control group received a 14โ€day regimen of amoxicillin, clarithromycin, bismuth, and esomeprazole, and 110 patients in the intervention group received 40 …

Continue reading Atorvastatin in combination with conventional antimicrobial treatment of #Helicobacter pylori eradication: A randomized controlled clinical trial