Central versus ambulatory blood pressure for predicting mortality and cardiovascular events in hemodialysis patients: a multicenter cohort study

Studies in the general population suggest that central blood pressure (BP) may be superior to peripheral BP in risk assessment. Although ambulatory brachial BP is recognized as the most reliable BP measurement in the dialysis population, there is no comparison of office central BP with ambulatory BP regarding risk stratification in these patients. Methods:In a… Continue reading Central versus ambulatory blood pressure for predicting mortality and cardiovascular events in hemodialysis patients: a multicenter cohort study

Early insight into #antibody-dependent enhancement after SARS-CoV-2 mRNA #vaccination

Current vaccines, which induce a B-cell-mediated antibody response against the spike protein of SARS-CoV-2, have markedly reduced infection rates. However, the emergence of new variants as a result of SARS-CoV-2 evolution requires the development of novel vaccines that are T-cell-based and that target mutant-specific spike proteins along with ORF1ab or nucleocapsid protein. This approach is… Continue reading Early insight into #antibody-dependent enhancement after SARS-CoV-2 mRNA #vaccination

Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection

Statins may be protective in SARS-CoV-2 infection. The aim of this study was to evaluate the effect of in-hospital statin use on 28-day mortality and ICU admission among patients with SARS-CoV-2 stratified into 4 groups: those who used statins prior to hospitalization (continued, discontinued) and those who did not (newly initiated, never). MethodsIn a cohort… Continue reading Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection

The Relationship Between Body #Mass Index and In-Hospital #Mortality in the Contemporary Era of an Acute Myocardial #Infarction Management

The association between body mass index (BMI) and clinical outcomes following an acute myocardial infarction (AMI) remains controversial. Our objective was to investigate the relationship between BMI and AMI presentation, in-hospital clinical course and mortality in the contemporary era of AMI management. Methods: Patients, hospitalized for an AMI between October 2015 and December 2016, were… Continue reading The Relationship Between Body #Mass Index and In-Hospital #Mortality in the Contemporary Era of an Acute Myocardial #Infarction Management

#Steps per Day and All-Cause #Mortality in Middle-aged Adultsin the Coronary Artery Risk Development in Young Adults Study

IMPORTANCE Steps per day is a meaningful metric for physical activity promotion in clinical andpopulation settings. To guide promotion strategies of step goals, it is important to understand theassociation of steps with clinical end points, including mortality. OBJECTIVE To estimate the association of steps per day with premature (age 41-65 years) all-causemortality among Black and… Continue reading #Steps per Day and All-Cause #Mortality in Middle-aged Adultsin the Coronary Artery Risk Development in Young Adults Study

Sudden death in individuals with obstructive sleep #apnoea: a systematic review and meta-analysis

Over 1 billion individuals worldwide experience some form of sleep apnoea, and this number is steadily rising. Obstructive sleep apnoea (OSA) can negatively influence one’s quality of life and potentially increase mortality risk. However, the association between OSA and mortality has not been reliably estimated. This meta-analysis estimates the risk of all-cause and cardiovascular mortality in… Continue reading Sudden death in individuals with obstructive sleep #apnoea: a systematic review and meta-analysis

Serum #albumin and risks of hospitalization and death: Findings from the #Atherosclerosis Risk in Communities study

To determine whether lower serum albumin in community-dwelling, older adults is associated with increased risk of hospitalization and death independent of pre-existing disease. DesignProspective cohort study of participants in the fifth visit of the Atherosclerosis Risk in Communities (ARIC) study. Baseline data were collected from 2011 to 2013. Follow-up was available to December 31, 2017.… Continue reading Serum #albumin and risks of hospitalization and death: Findings from the #Atherosclerosis Risk in Communities study

Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort

RBC long-chain omega-3 (n–3) fatty acid (FA) percentages (of total fatty acids) are associated with lower risk for total mortality, but it is unknown if a suite of FAs could improve risk prediction. ObjectivesThe objective of this study was to compare a combination of RBC FA levels with standard risk factors for cardiovascular disease (CVD)… Continue reading Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort

#Hydroxychloroquine and Mortality Among Patients With Systemic #Lupus Erythematosus in the General Population

Hydroxychloroquine (HCQ) has been associated with improved survival among patients with systemic lupus erythematosus (SLE) from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. MethodsWe conducted a nested case–control study within an incident SLE cohort from the entire… Continue reading #Hydroxychloroquine and Mortality Among Patients With Systemic #Lupus Erythematosus in the General Population