Studies on the association between proton pump inhibitor (PPI) use and dementia report mixed results and do not examine the impact of cumulative PPI use. We evaluated the associations between current and cumulative PPI use and risk of incident dementia in the Atherosclerosis Risk in Communities (ARIC) Study.Methods. These analyses used participants from a community-based cohort… Continue reading Cumulative Use of #Proton Pump Inhibitors and Risk of #Dementia: The Atherosclerosis Risk in Communities Study
High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
Highlights•Studies have shown that high PTH was associated with NAFLD/NASH, although the results from existing studies are inconsistent.•Using systematic review, 10 and 4 studies reported the association of PTH with NAFLD and NASH, respectively.•The meta-analysis suggested that high PTH can be a marker of NAFLD.•The meta-analysis also revealed that high PTH tended to be associated… Continue reading High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
Association between added #sugars and kidney #stones in U.S. adults: data from National Health and Nutrition Examination Survey 2007–2018
Added sugar is associated with a variety of adverse health outcomes, but its association with kidney stones is unclear. This study was to determine whether added sugar is associated with kidney stones.Materials and methods: This nationally representative study used National Health and Nutrition Examination Survey (NHANES) datasets from 2007 to 2018 for analysis. People aged ≥20 years… Continue reading Association between added #sugars and kidney #stones in U.S. adults: data from National Health and Nutrition Examination Survey 2007–2018
Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
The risk of cardiovascular disease is increased among persons with human immunodeficiency virus (HIV) infection, so data regarding primary prevention strategies in this population are needed.METHODSIn this phase 3 trial, we randomly assigned 7769 participants with HIV infection with a low-to-moderate risk of cardiovascular disease who were receiving antiretroviral therapy to receive daily pitavastatin calcium… Continue reading Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
Cause-specific excess #mortality after first diagnosis of #bipolar disorder: population-based cohort study
Background Bipolar disorder (BD) is associated with increased mortality, but evidence on cause-specific mortality is limited.Objective To investigate cause-specific premature excess mortality in BD.Methods Finnish nationwide cohort study of individuals with and without a diagnosis of BD who were aged 15–64 years during 2004–2018. Standardised mortality ratios (SMRs) with 95% CIs were calculated for BD using the mortality… Continue reading Cause-specific excess #mortality after first diagnosis of #bipolar disorder: population-based cohort study
Human #cells experience a #Zn2+ pulse in early G1
Highlights•Human cells experience a transient zinc pulse in early G1•The magnitude of the pulse tracks with the amount of zinc in the cytosol and media•Knockdown of MTF-1 decreases metallothionein and increases the zinc pulse•Cells pause proliferation until labile cellular zinc is in the optimum range SummaryZinc is an essential micronutrient required for all domains of… Continue reading Human #cells experience a #Zn2+ pulse in early G1
Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
Metformin, a first-line medication for type 2 diabetes, might also have a protective effect against ageing-related diseases, but so far little experimental evidence is available. We sought to assess the target-specific effect of metformin on biomarkers of ageing in the UK Biobank.MethodsIn this drug target mendelian randomisation study, we assessed the target-specific effect of four… Continue reading Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
#Kombucha tea as an anti-hyperglycemic agent in humans with #diabetes – a randomized controlled pilot investigation
Introduction: Kombucha is a popular fermented tea that has attracted considerable attention due, in part, to its suggested health benefits. Previous results from animal models led us to hypothesize kombucha may reduce blood sugar levels in humans with diabetes. The objective of this pilot clinical study was to evaluate kombucha for its anti-hyperglycemic activities in adults… Continue reading #Kombucha tea as an anti-hyperglycemic agent in humans with #diabetes – a randomized controlled pilot investigation
(P06-010-23) Determination of the #Prebiotic Content of #Foods in the 2015-2016 Food and #Nutrient Database for Dietary Studies (FNDDS)
Consuming prebiotics positively impacts health. According to the International Scientific Association for Probiotics and Prebiotics (ISAPP), the recognized prebiotics include inulin-like fructans (inulin, FOS, oligofructose) and GOS, and 5 g/d consumed is the minimum needed to confer a health benefit. Currently, there is no database that provides the prebiotic content of food based on these… Continue reading (P06-010-23) Determination of the #Prebiotic Content of #Foods in the 2015-2016 Food and #Nutrient Database for Dietary Studies (FNDDS)
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