Abstract: Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease needing effective therapeutics urgently. Sildenafil, one of the approved phosphodiesterase-5 inhibitors, has been implicated as having potential effect in AD. Objective: To investigate the potential therapeutic benefit of sildenafil on AD. Methods: We performed real-world patient data analysis using the MarketScan® Medicare Supplemental and the Clinformatics®… Continue reading #Sildenafil as a Candidate Drug for #Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
Effectiveness of Seizure #Dogs for People With Severe Refractory #EpilepsyResults From the EPISODE Study
Background and ObjectivesThe aim of this study was to evaluate whether people living with severe medically refractory epilepsy (PSRE) benefit from a seizure dog.MethodsAn individual-level stepped-wedge randomized controlled trial was conducted. The study was conducted in the Netherlands among adults with daily to weekly seizures. All participants were included simultaneously (on June 1, 2019) while… Continue reading Effectiveness of Seizure #Dogs for People With Severe Refractory #EpilepsyResults From the EPISODE Study
Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
IntroductionApproximately 30% to 50% residual β-cell function may remain at the time of type 1 diabetes (T1D) diagnosis, and this may persist for months or years.1,2 A prolonged partial remission (PR) phase of T1D leads to improved glycemic control and decreased long-term complications.1 We previously reported1 that ergocalciferol significantly decreased circulating tumor necrosis factor (TNF)-α and temporal trends… Continue reading Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
Dissecting abstract, modality-specific and experience-dependent coding of affect in the human #brain
#Emotion and #perception are tightly intertwined, as affective experiences often arise from the appraisal of sensory information. Nonetheless, whether the brain encodes emotional instances using a sensory-specific code or in a more abstract manner is unclear. Here, we answer this question by measuring the association between emotion ratings collected during a unisensory or multisensory presentation… Continue reading Dissecting abstract, modality-specific and experience-dependent coding of affect in the human #brain
Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive… Continue reading Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
#Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of #COVID-19
Persistent symptoms following SARS-CoV-2 infection are increasingly reported, although the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 individuals infected with SARS-CoV-2, with varying disease severity, for one year from COVID-19 symptom onset to determine the early correlates of PASC. A multivariate signature detected beyond two weeks of disease, encompassing… Continue reading #Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of #COVID-19
Prospective Associations of Accelerometer‐Measured Machine‐Learned #Sedentary Behavior With Death Among Older Women: The OPACH Study
BackgroundSedentary behavior is a recognized mortality risk factor. The novel and validated convolutional neural network hip accelerometer posture algorithm highly accurately classifies sitting and postural changes compared with accelerometer count cut points. We examined the prospective associations of convolutional neural network hip accelerometer posture–classified total sitting time and mean sitting bout duration with all‐cause and… Continue reading Prospective Associations of Accelerometer‐Measured Machine‐Learned #Sedentary Behavior With Death Among Older Women: The OPACH Study
Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
BackgroundCaffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption behaviour and metabolism. This study aimed to investigate the effects of circulating caffeine levels by considering genetically predicted variation in caffeine metabolism.MethodsLeveraging genetic variants related to… Continue reading Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
Ultra-processed #food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses
AbstractObjective To evaluate the existing meta-analytic evidence of associations between exposure to ultra-processed foods, as defined by the Nova food classification system, and adverse health outcomes.Design Systematic umbrella review of existing meta-analyses.Data sources MEDLINE, PsycINFO, Embase, and the Cochrane Database of Systematic Reviews, as well as manual searches of reference lists from 2009 to June 2023.Eligibility criteria for… Continue reading Ultra-processed #food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses
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