Objective To prospectively assess the effect of endometriosis and uterine fibroids on the long term risk of premature mortality (younger than 70 years).Design Prospective cohort studySetting The Nurses’ Health Study II, United States (1989-2019).Participants 110 091 women aged 25-42 years in 1989 without a history of hysterectomy before endometriosis or fibroids diagnosis, cardiovascular diseases, or cancer.Main… Continue reading #Endometriosis and uterine #fibroids and risk of premature mortality: prospective cohort study
Distinct risk groups with different healthcare barriers and acute care use exist in the U.S. population with chronic #liver disease
BackgroundThe relationship between community-based healthcare barriers and risk of recurrent hospital-based care among persons with chronic liver disease (CLD) is understudied. We aimed to uncover distinct groups among adults in the United States with CLD based on healthcare barriers and risk-stratify recurrent acute care use by group.MethodsUsing National Health Interview Survey (2011 to 2017) data,… Continue reading Distinct risk groups with different healthcare barriers and acute care use exist in the U.S. population with chronic #liver disease
#Cocoa flavanols rescue #stress-induced declines in endothelial function after a high-fat meal, but do not affect cerebral oxygenation during stress in young, healthy adults
Food choices during stressful periods often worsen, which can influence the impact of stress on vascular health. For instance, fat consumption impairs the recovery of endothelial function following mental stress, while flavanols have been shown to enhance recovery. This randomised, counterbalanced, double-blinded, crossover, postprandial intervention study examined whether flavanols consumed in combination with fat can… Continue reading #Cocoa flavanols rescue #stress-induced declines in endothelial function after a high-fat meal, but do not affect cerebral oxygenation during stress in young, healthy adults
Non-fermented and fermented #milk intake in relation to risk of ischemic #heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants
BackgroundThe effect of milk on the risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) is unclear. We aimed to examine the association between non-fermented and fermented milk consumption on these endpoints and investigate the relationship between milk intake and cardiometabolic-related proteins in plasma.MethodsOur study is based on two Swedish prospective cohort studies… Continue reading Non-fermented and fermented #milk intake in relation to risk of ischemic #heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants
Accelerometer-Measured #Sedentary Behavior and Risk of Future #Cardiovascular Disease
BackgroundBeyond serving as a marker for insufficient physical activity, sedentary behavior may directly affect future cardiovascular (CV) disease risk.ObjectivesThis study sought to examine associations between accelerometer-measured sedentary behavior with risk of specific CV outcomes, including potential relations with moderate to vigorous physical activity (MVPA).MethodsAmong participants of the UK Biobank prospective cohort study, we fit Cox… Continue reading Accelerometer-Measured #Sedentary Behavior and Risk of Future #Cardiovascular Disease
Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study
BackgroundHealthy diets have been inversely associated with biological aging. However, the nutritional content is only one aspect of the overall food health potential, and more recently, increasing attention has been paid to nonnutrient food characteristics, such as food processing.ObjectivesTo examine the association of ultra-processed food (UPF) consumption with biological aging measured by circulating blood biomarkers.MethodsCross-sectional… Continue reading Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study
Blood #Pressure Decreases in #Overweight Elderly Individuals on Vitamin #D: A Randomized Trial
AbstractContextEvidence for a beneficial role of vitamin D on blood pressure (BP) outcomes is inconclusive.ObjectiveThis work aimed to investigate the effect of 2 doses of cholecalciferol (vitamin D3) supplementation coadministered with calcium on systolic blood pressure (SBP) and diastolic blood pressure (DBP).MethodsExploratory analyses were conducted from a 1-year, multicenter, double-blind, randomized controlled trial (RCT). Total… Continue reading Blood #Pressure Decreases in #Overweight Elderly Individuals on Vitamin #D: A Randomized Trial
Device-Measured 24-Hour Movement Behaviors and Blood #Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium
BACKGROUND:Blood pressure (BP)–lowering effects of structured exercise are well-established. Effects of 24-hour movement behaviors captured in free-living settings have received less attention. This cross-sectional study investigated associations between a 24-hour behavior composition comprising 6 parts (sleeping, sedentary behavior, standing, slow walking, fast walking, and combined exercise-like activity [eg, running and cycling]) and systolic BP (SBP)… Continue reading Device-Measured 24-Hour Movement Behaviors and Blood #Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium
Gut #microbiota regulates #stress responsivity via the circadian system
SummaryStress and circadian systems are interconnected through the hypothalamic-pituitary-adrenal (HPA) axis to maintain responses to external stimuli. Yet, the mechanisms of how such signals are orchestrated remain unknown. Here, we uncover the gut microbiota as a regulator of HPA-axis rhythmicity. Microbial depletion disturbs the brain transcriptome and metabolome in stress-responding pathways in the hippocampus and… Continue reading Gut #microbiota regulates #stress responsivity via the circadian system
