A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular for weight loss, detrimental effects have also been reported. Here, we show mice on two different KDs and, at different ages, induce cellular senescence in multiple organs, including the heart… Continue reading #Ketogenic diet induces p53-dependent cellular #senescence in multiple organs
Real-world data of radiofrequency catheter #ablation in paroxysmal atrial #fibrillation: Short- and long-term clinical outcomes from the prospective multicenter REAL-AF Registry
BackgroundThe safety and long-term efficacy of radiofrequency (RF) catheter ablation (CA) of paroxysmal atrial fibrillation (PAF) has been well established. Contemporary techniques to optimize ablation delivery, reduce fluoroscopy use, and improve clinical outcomes have been developedObjectiveThe purpose of this study was to assess the contemporary real-world practice approach and long-term outcomes of RF CA for… Continue reading Real-world data of radiofrequency catheter #ablation in paroxysmal atrial #fibrillation: Short- and long-term clinical outcomes from the prospective multicenter REAL-AF Registry
‘Death by 1000 Cuts’: Medscape National #Physician #Burnout & #Suicide Report 2021
Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory
Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM… Continue reading Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory
The microbiome-driven impact of western #diet in the development of noncommunicable chronic disorders
Noncommunicable chronic disorders (NCDs) are multifactorial disorders that share a state of chronic, low-grade inflammation together with an imbalance of gut microbiota. NCDs are becoming increasingly prevalent worldwide, and mainly in Western countries, with a significant impact on global health.Societal changes, together with the widespread diffusion of modern agricultural methods and food processing, have led… Continue reading The microbiome-driven impact of western #diet in the development of noncommunicable chronic disorders
Sex differences in #adipose #insulin resistance are linked to #obesity, lipolysis and insulin receptor substrate 1
Background/ObjectiveInsulin resistance is more prominent in men than women. If this involves adipose tissue is unknown and was presently examined.Subjects/MethodsAdipoIR (in vivo adipose insulin resistance index) was measured in 2344 women and 787 men. In 259 of the women and 54 of the men, insulin induced inhibition of lipolysis (acylglycerol breakdown) and stimulation of lipogenesis… Continue reading Sex differences in #adipose #insulin resistance are linked to #obesity, lipolysis and insulin receptor substrate 1
The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity
BackgroundInflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. LRRK2 has been implicated as playing a role in both diseases. Exploring the genetic basis of the IBD-PD comorbidity through studying high-impact rare genetic variants can facilitate the identification of the novel shared genetic factors underlying this… Continue reading The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity
Wearing face #masks did not reduce risk of #COVID infection after first Omicron wave, research shows
After the first Omicron wave, research shows that many of the risks of Covid infection changed Before February 2022, always wearing face masks and being retired were associated with reduced risk, but not after Overseas travel was not associated with increased risk prior to February 2022, but then became a significant risk Peer reviewed – meta-regression- humans New… Continue reading Wearing face #masks did not reduce risk of #COVID infection after first Omicron wave, research shows
Association of ultra-processed #food consumption with all cause and cause specific #mortality: population based cohort study
Objective To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality.Design Population based cohort study.Setting Female registered nurses from 11 US states in the Nurses’ Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018).Participants 74 563 women and 39 501 men with no history of… Continue reading Association of ultra-processed #food consumption with all cause and cause specific #mortality: population based cohort study
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