Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory

Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM… Continue reading Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory

The microbiome-driven impact of western #diet in the development of noncommunicable chronic disorders

Noncommunicable chronic disorders (NCDs) are multifactorial disorders that share a state of chronic, low-grade inflammation together with an imbalance of gut microbiota. NCDs are becoming increasingly prevalent worldwide, and mainly in Western countries, with a significant impact on global health.Societal changes, together with the widespread diffusion of modern agricultural methods and food processing, have led… Continue reading The microbiome-driven impact of western #diet in the development of noncommunicable chronic disorders

Sex differences in #adipose #insulin resistance are linked to #obesity, lipolysis and insulin receptor substrate 1

Background/ObjectiveInsulin resistance is more prominent in men than women. If this involves adipose tissue is unknown and was presently examined.Subjects/MethodsAdipoIR (in vivo adipose insulin resistance index) was measured in 2344 women and 787 men. In 259 of the women and 54 of the men, insulin induced inhibition of lipolysis (acylglycerol breakdown) and stimulation of lipogenesis… Continue reading Sex differences in #adipose #insulin resistance are linked to #obesity, lipolysis and insulin receptor substrate 1

The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity

BackgroundInflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. LRRK2 has been implicated as playing a role in both diseases. Exploring the genetic basis of the IBD-PD comorbidity through studying high-impact rare genetic variants can facilitate the identification of the novel shared genetic factors underlying this… Continue reading The landscape of rare genetic variation associated with inflammatory #bowel disease and #Parkinson’s disease comorbidity

Wearing face #masks did not reduce risk of #COVID infection after first Omicron wave, research shows 

After the first Omicron wave, research shows that many of the risks of Covid infection changed Before February 2022, always wearing face masks and being retired were associated with reduced risk, but not after Overseas travel was not associated with increased risk prior to February 2022, but then became a significant risk Peer reviewed – meta-regression- humans  New… Continue reading Wearing face #masks did not reduce risk of #COVID infection after first Omicron wave, research shows 

Association of ultra-processed #food consumption with all cause and cause specific #mortality: population based cohort study

Objective To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality.Design Population based cohort study.Setting Female registered nurses from 11 US states in the Nurses’ Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018).Participants 74 563 women and 39 501 men with no history of… Continue reading Association of ultra-processed #food consumption with all cause and cause specific #mortality: population based cohort study

Use of ancient #grains for the management of #diabetes mellitus: A systematic review and meta-analysis

Highlights•Oats, brown rice, and millet improve health outcomes in diabetes mellitus type 2.•The most prevalent grains tested in trials included oats, brown rice, and buckwheat.•The most outcomes studied in diabetes were related to cardiovascular risk factors.AimsA systematic review and meta-analysis of published randomized controlled trials was conducted to collate evidence from studies implementing ancient grains… Continue reading Use of ancient #grains for the management of #diabetes mellitus: A systematic review and meta-analysis

Consumption of #Olive Oil and Diet Quality and Risk of #Dementia-Related Death

Question  Is the long-term consumption of olive oil associated with dementia-related death risk? Findings  In a prospective cohort study of 92 383 adults observed over 28 years, the consumption of more than 7 g/d of olive oil was associated with a 28% lower risk of dementia-related death compared with never or rarely consuming olive oil, irrespective of diet… Continue reading Consumption of #Olive Oil and Diet Quality and Risk of #Dementia-Related Death