Background and ObjectivesHypertension is a well-established cardiovascular risk factor for cognitive function. As blood pressure fluctuates because of aging-related changes, we examined the association between visit-to-visit blood pressure variability (BPV) and cognition in older adults. MethodsThis prospective observational cohort study included 4,770 individuals aged older than 65 years with repeated blood pressure assessment participating in… Continue reading Blood #Pressure Variability and #Cognition in Black and White Older Adults Over 18 Years of Follow-up
Urinary #tartaric acid as a biomarker of #wine consumption and #cardiovascular risk: the PREDIMED trial
Background and AimsModerate wine consumption has been associated with lower cardiovascular disease (CVD) risk in older populations. However, wine consumption information through self-reports is prone to measurement errors inherent to subjective assessments. The aim of this study was to evaluate the association between urinary tartaric acid, an objective biomarker of wine consumption, and the rate… Continue reading Urinary #tartaric acid as a biomarker of #wine consumption and #cardiovascular risk: the PREDIMED trial
Long-Term #Aspirin vs #Clopidogrel After #Coronary Stenting by Bleeding Risk and Procedural Complexity
Question What is the comparative effectiveness of clopidogrel vs aspirin monotherapy in the chronic maintenance period after percutaneous coronary intervention (PCI) according to bleeding risk and procedural complexity?Findings In this post hoc analysis of the HOST-EXAM Extended clinical trial, clopidogrel monotherapy was associated with a reduction in thrombotic and bleeding risks compared with aspirin, regardless… Continue reading Long-Term #Aspirin vs #Clopidogrel After #Coronary Stenting by Bleeding Risk and Procedural Complexity
Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms
Highlights•The regular consumption of moderate doses of coffee attenuates all-cause mortality•Coffee intake attenuates age-associated diseases (cardiovascular, stroke, cancer)•Coffee and its main components (caffeine, chlorogenic acids) control stress adaptation•Coffee intake preserves the main biological mechanisms of aging AbstractThe conception of coffee consumption has undergone a profound modification, evolving from a noxious habit into a safe lifestyle… Continue reading Impact of #coffee intake on human #aging: Epidemiology and cellular mechanisms
Associations of accelerometer-measured #physical activity, #sedentary behaviour, and #sleep with next-day #cognitive performance in older adults: a micro-longitudinal study
BackgroundPrevious studies suggest short-term cognitive benefits of physical activity occurring minutes to hours after exercise. Whether these benefits persist the following day and the role of sleep is unclear. We examined associations of accelerometer-assessed physical activity, sedentary behaviour, and sleep with next-day cognitive performance in older adults.MethodsBritish adults aged 50-83 years (N = 76) without evidence of… Continue reading Associations of accelerometer-measured #physical activity, #sedentary behaviour, and #sleep with next-day #cognitive performance in older adults: a micro-longitudinal study
Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
BackgroundInternational guidelines suggest screening for advanced fibrosis due to metabolic dysfunction-associated steatotic liver disease in people with type 2 diabetes, but how to implement these guidelines in clinical care remains unclear. We hypothesise that examination with VCTE could be implemented simultaneously with retina scanning with a high acceptance rate in people with type 2 diabetes.… Continue reading Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
#Empagliflozin and the Risk of #Retinopathy in Patients With Type 2 Diabetes
Question Is there an association between empagliflozin and the risk of nonproliferative diabetic retinopathy (NPDR) and diabetic retinopathy (DR) progression in patients with type 2 diabetes (T2D)?Findings In this cohort study, there was no association between empagliflozin and incident NPDR in patients with T2D who had no DR history; however, empagliflozin was associated with a… Continue reading #Empagliflozin and the Risk of #Retinopathy in Patients With Type 2 Diabetes
Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected #SepsisThe ADAPT-Sepsis Randomized Clinical Trial
Question Do critically ill adult patients hospitalized for suspected sepsis and treated with intravenous antibiotics based on procalcitonin (PCT) or C-reactive protein (CRP) protocols, have a safe reduction in treatment duration compared with standard care?Findings In this multicenter, randomized trial of 2760 patients, the daily PCT-guided protocol reduced total antibiotic duration and had noninferior all-cause… Continue reading Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected #SepsisThe ADAPT-Sepsis Randomized Clinical Trial
Device-measured vigorous intermittent lifestyle #physical activity (VILPA) and major adverse cardiovascular events: evidence of sex differences
Background Vigorous intermittent lifestyle physical activity (VILPA) refers to brief bouts of intense physical activity embedded into daily life.Objective To examine sex differences in the dose–response association of VILPA with major adverse cardiovascular events (MACE) and its subtypes.Methods Using multivariable-adjusted cubic splines, we examined the associations of daily VILPA duration with overall MACE and its… Continue reading Device-measured vigorous intermittent lifestyle #physical activity (VILPA) and major adverse cardiovascular events: evidence of sex differences
2 Medical News 