Fecal microbiota transplantation (#FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor… Continue reading Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Convergent evidence for predispositional effects of #brain gray matter volume on #alcohol consumption
Smaller right dorsolateral prefrontal cortex (DLPFC; i.e., middle and superior frontal gyri) and insula GMVs were associated with increased alcohol use across samples. Family-based and prospective longitudinal data suggest these associations are genetically-conferred and that DLPFC GMV prospectively predicts future use and initiation. Genomic risk for alcohol use was enriched in gene-sets preferentially expressed in… Continue reading Convergent evidence for predispositional effects of #brain gray matter volume on #alcohol consumption
Comparing the burdens of opportunistic #infections among patients with systemic #rheumatic diseases: a nationally representative cohort study
The IR of opportunistic infections was highest for PM/DM cases (61.3/1000 person-years, 95% confidence interval [CI] 56.6–66.2), followed by SLE cases (43.1/1000 person-years, 95% CI 41.7–44.5), SSc cases (31.6/1000 person-years, 95% CI 28.3–35.1), RA cases (25.0/1000 person-years, 95% CI 24.4–25.7), and pSS cases (24.1/1000 person-years, 95% CI 23.1–25.2). Multivariable Cox analysis revealed that, relative to… Continue reading Comparing the burdens of opportunistic #infections among patients with systemic #rheumatic diseases: a nationally representative cohort study
Efficacy and safety of #anti-inflammatory agents for the treatment of major #depressive disorder: a systematic review and meta-analysis of randomised controlled trials
..Four studies explored the antidepressant effects of NSAIDs in addition to traditional antidepressants. In all four studies, celecoxib was added at the same dose (400 mg/day). Traditional antidepressants used were sertraline, fluoxetine and reboxetine. We combined these studies for a subgroup meta-analysis, finding that antidepressants combined with celecoxib were better than antidepressants alone, leading to a… Continue reading Efficacy and safety of #anti-inflammatory agents for the treatment of major #depressive disorder: a systematic review and meta-analysis of randomised controlled trials
Serum elaidic acid concentration and risk of #dementia. The Hisayama study
The associations between #trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for… Continue reading Serum elaidic acid concentration and risk of #dementia. The Hisayama study
Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or #obese
Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness ..exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44±2.63% versus 1.44±4.18% area lipid staining, p < 0.01) and type II fibres (-1.89±2.48% versus 1.83±1.92% area lipid staining, p < 0.05). Training Study -… Continue reading Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or #obese
#Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database
Among the 3900 patients aged 80 years and older, 2 years of statin prescriptions resulted in a lower risk of the composite outcome (adjusted HR = 0.81; 95% confidence interval [CI] = 0.66‐0.99) and of all‐cause mortality (adjusted HR = 0.84; 95% CI = 0.73‐0.97). During 4.5 years of median follow‐up, the NNT for prevention of the primary outcome… Continue reading #Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database
Comparison of #fracture risk using different supplemental doses of #vitamin D, #calcium or their combination: a network meta-analysis of randomised controlled trials
Inconsistent findings in regard to association between different concentrations of vitamin D, calcium or their combination and the risk of fracture have been reported during the past decade in community-dwelling older people A total of 25 randomised controlled trials involving 43 510 participants fulfilled the inclusion criteria. There was no evidence that the risk of… Continue reading Comparison of #fracture risk using different supplemental doses of #vitamin D, #calcium or their combination: a network meta-analysis of randomised controlled trials
Dietary #salt promotes cognitive impairment through tau phosphorylation
Dietary habits and vascular risk factors promote both #Alzheimer’s disease and cognitive impairment caused by vascular factors. Furthermore, accumulation of hyperphosphorylated tau, a microtubule-associated protein and a hallmark of Alzheimer’s pathology, is also linked to vascular cognitive impairment. In mice, a salt-rich diet leads to cognitive dysfunction associated with a nitric oxide deficit in cerebral… Continue reading Dietary #salt promotes cognitive impairment through tau phosphorylation
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