..We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care. ..We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities.… Continue reading Are symptoms of #insomnia in primary care associated with subsequent onset of #dementia? A matched retrospective case-control study
#BPA: have flawed analytical techniques compromised risk assessments?
Experimental and epidemiological studies provide compelling evidence of a causal link between increasing exposure to endocrine-disrupting chemicals (environmental contaminants with the potential to perturb the development and function of the endocrine system) and increases in non-communicable diseases, including most aspects of metabolic syndrome.. ..By virtue of extensive research attention, bisphenol A (BPA) has become the… Continue reading #BPA: have flawed analytical techniques compromised risk assessments?
Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 #Diabetes Consuming a Three- #Meal Diet: A Randomized Clinical Trial
In type 2 diabetes, insulin resistance and progressive β-cell failure require treatment with high insulin doses, leading to weight gain. Our aim was to study whether a three-meal diet (3Mdiet) with a carbohydrate-rich breakfast may upregulate clock gene expression and, as a result, allow dose reduction of insulin, leading to weight loss and better glycemic… Continue reading Reduction in Glycated Hemoglobin and Daily Insulin Dose Alongside Circadian Clock Upregulation in Patients With Type 2 #Diabetes Consuming a Three- #Meal Diet: A Randomized Clinical Trial
Association Between #Marijuana Use and Risk of #Cancer A Systematic Review and Meta-analysis
.. In pooled analysis of case-control studies, ever use of marijuana was not associated with head and neck squamous cell carcinoma or oral cancer. In pooled analysis of 3 case-control studies, more than 10 years of marijuana use (joint-years not reported) was associated with TGCT (OR, 1.36; 95% CI, 1.03-1.81; P = .03; I2 = 0%) and nonseminoma TGCT… Continue reading Association Between #Marijuana Use and Risk of #Cancer A Systematic Review and Meta-analysis
#Skin barrier damage after exposure to para-phenylenediamine
p-Phenylenediamine (#PPD) is a strong contact allergen used in hair dye known to cause allergic contact dermatitis (ACD). Both private and occupational exposure to PPD is frequent, but the effect of PPD exposure in non-allergic occupational exposed individuals is unknown.. ..RNA-sequencing demonstrated down-regulation of tight junction (TJ) and stratum corneum (SC) proteins in skin of… Continue reading #Skin barrier damage after exposure to para-phenylenediamine
Association between #dairy product consumption and #hyperuricemia in an elderly population with metabolic syndrome
The prevalence of hyperuricemia has increased substantially in recent decades. It has been suggested that it is an independent risk factor for weight gain, hypertension, hypertriglyceridemia, metabolic syndrome (#MetS), and cardiovascular disease.. ..Participants in the upper quartile of the consumption of total dairy products (multiadjusted prevalence ratio (PR) = 0.84; 95% CI: 0.75–0.94; P-trend 0.02),… Continue reading Association between #dairy product consumption and #hyperuricemia in an elderly population with metabolic syndrome
Precipitation and #Climate Zone Explains the Geographical Disparity in the Invasive #Cancer Incidence Rates in the United States
Environmental factors such as ultraviolet radiation and pollution have been known to influence the incidence rate of cancer. However, these factors do not explain the variation in incidence rates across the United States.. ..Precipitation and climate zone were included in each model along with demographic variables such as annual income, population by gender, race, and… Continue reading Precipitation and #Climate Zone Explains the Geographical Disparity in the Invasive #Cancer Incidence Rates in the United States
Maternal #diabetes during pregnancy and early onset of #cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
To evaluate the associations between maternal diabetes diagnosed before or during pregnancy and early onset cardiovascular disease (CVD) in offspring during their first four decades of life. ..Offspring of mothers with diabetes had a 29% increased overall rate of early onset CVD (hazard ratio 1.29 (95% confidence interval 1.21 to 1.37); cumulative incidence among offspring… Continue reading Maternal #diabetes during pregnancy and early onset of #cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
Association Between #Beverage Intake and Incidence of Gastroesophageal #Reflux Symptoms
..Patients are frequently advised to eliminate coffee, tea, and/or soda to reduce symptoms of gastroesophageal reflux (GER), such as heartburn or regurgitation. ..After multivariable adjustment, hazard ratios (HRs) for women with the highest intake of each beverage (more than 6 servings/day) compared to women with the lowest intake (0 servings/day) were 1.34 for coffee (95%… Continue reading Association Between #Beverage Intake and Incidence of Gastroesophageal #Reflux Symptoms
2 Medical News 