Many adults become vitamin D deficient or insufficient during winter at northerly latitudes when cutaneous vitamin D synthesis does not occur. Vitamin D accumulates in adipose tissue and people with overweight or obesity are more likely to have low systemic vitamin D. This randomized controlled trial demonstrates that regular exercise completely maintains serum concentrations of… Continue reading #Exercise without Weight Loss Prevents Seasonal Decline in Vitamin #D Metabolites: The VitaDEx Randomized Controlled Trial
#Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
BackgroundNon-remission after psychological therapy for major depressive disorder is common, yet there are no established further-line treatments. In the UK National Health Service (NHS) Talking Therapies programme, about 50% of patients with depression who come to the end of the stepped care pathway do not show remission of symptoms. We aimed to investigate whether mindfulness-based… Continue reading #Mindfulness-based cognitive therapy versus treatment as usual after non-remission with NHS Talking Therapies high-intensity psychological therapy for depression: a UK-based clinical effectiveness and cost-effectiveness randomised, controlled, superiority trial
Long-term trials of #colchicine for secondary prevention of #vascular events: a meta-analysis
Background and AimsColchicine has emerged as a safe and inexpensive anti-inflammatory medication to target the residual risk of cardiovascular events in the secondary prevention of coronary artery disease. Two recently published randomized controlled trials (RCTs) investigating colchicine in the post-stroke and post-myocardial infarction (MI) populations warrant a re-evaluation of colchicine. New evidence was synthesized in… Continue reading Long-term trials of #colchicine for secondary prevention of #vascular events: a meta-analysis
Impact of #mRNA and Inactivated COVID-19 Vaccines on #Ovarian Reserve
Objectives: This study aimed to elucidate the effects of messenger RNA (mRNA) and inactivated coronavirus disease 2019 (COVID-19) vaccines on ovarian histology and reserve in rats. Methods: Thirty female Wistar albino rats, aged 16–24 weeks, were randomly divided into three groups (n = 10): control, mRNA vaccine, and inactivated vaccine groups. Each vaccine group received… Continue reading Impact of #mRNA and Inactivated COVID-19 Vaccines on #Ovarian Reserve
Mammographic classification of interval breast cancers and #artificial intelligence performance
European studies suggest artificial intelligence (AI) can reduce interval breast cancers (IBCs). However, research on IBC classification and AI’s effectiveness in the U.S., particularly using digital breast tomosynthesis (DBT) and annual screening, is limited. We aimed to mammographically classify IBCs and assess AI performance using a 12-month screening interval.MethodsFrom digital mammography (DM) and DBT screening… Continue reading Mammographic classification of interval breast cancers and #artificial intelligence performance
#Social media use in adolescents with and without #mental health conditions
Concerns about the relationship between social media use and adolescent mental health are growing, yet few studies focus on adolescents with clinical-level mental health symptoms. This limits our understanding of how social media use varies across mental health profiles. In this Registered Report, we analyse nationally representative UK data (N = 3,340, aged 11–19 years) including diagnostic assessments… Continue reading #Social media use in adolescents with and without #mental health conditions
#Vagus nerve stimulation therapy for treatment-resistant #PTSD
BackgroundPosttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We developed a fundamentally novel neuromodulation-based therapy for treatment-resistant PTSD. This approach is premised on coupling prolonged exposure therapy, a first-line evidence-based cognitive behavioral therapy that directs changes within fear networks, with concurrent delivery of short bursts of… Continue reading #Vagus nerve stimulation therapy for treatment-resistant #PTSD
Evaluation of an Ambient Artificial Intelligence Documentation Platform for #Clinicians
Importance The increase of electronic health record (EHR) work negatively impacts clinician well-being. One potential solution is incorporating an ambient artificial intelligence (AI) documentation platform.Objective To understand clinician experience before and after implementing ambient AI.Design, Setting, and Participants This quality improvement study was a pilot evaluation with before and after survey and EHR metrics conducted… Continue reading Evaluation of an Ambient Artificial Intelligence Documentation Platform for #Clinicians
Integrative analysis reveals therapeutic potential of #pyrvinium pamoate in #Merkel cell carcinoma
Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine cutaneous malignancy arising from either ultraviolet-induced mutagenesis or Merkel cell polyomavirus (MCPyV) integration. Despite extensive research, our understanding of the molecular mechanisms driving the transition from normal cells to MCC remains limited. To address this knowledge gap, we assessed the impact of inducible MCPyV T antigens on… Continue reading Integrative analysis reveals therapeutic potential of #pyrvinium pamoate in #Merkel cell carcinoma
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