High-throughput and rapid serology assays to detect the antibody response specific to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in human blood samples are urgently required to improve our understanding of the effects of COVID-19 across the world. Short-term applications include rapid case identification and contact tracing to limit viral spread, while population screening to determine the… Continue reading Rapid Gel Card Agglutination Assays for Serological Analysis Following #SARS-CoV-2 Infection in Humans
High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger #Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
The clinical spectra of irritable bowel syndrome (#IBS) and inflammatory bowel disease (#IBD) intersect to form a scantily defined overlap syndrome, termed pre-IBD. We show that increased Enterobacteriaceae and reduced Clostridia abundance distinguish the fecal microbiota of pre-IBD patients from IBS patients. A history of antibiotics in individuals consuming a high-fat diet was associated with… Continue reading High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger #Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
Nonalcoholic Fatty #Liver Disease and Advanced Fibrosis in US Adults Across Blood Pressure Categories
Nonalcoholic fatty liver disease (#NAFLD) is common in patients with hypertension but controversy exists as to whether screening for this condition should be performed. Here, we evaluate the prevalence of NAFLD and advanced fibrosis in US adults across blood pressure categories and estimate the number of patients who require referral to hepatologists. In this cross-sectional… Continue reading Nonalcoholic Fatty #Liver Disease and Advanced Fibrosis in US Adults Across Blood Pressure Categories
Association between #prediabetes and risk of all cause mortality and #cardiovascular disease: updated meta-analysis
To evaluate the associations between prediabetes and the risk of all cause mortality and incident cardiovascular disease in the general population and in patients with a history of atherosclerotic cardiovascular disease.. ..A total of 129 studies were included, involving 10 069 955 individuals for analysis. In the general population, prediabetes was associated with an increased risk of… Continue reading Association between #prediabetes and risk of all cause mortality and #cardiovascular disease: updated meta-analysis
Initiating Pharmacologic Treatment in #Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline
Current tobacco treatment guidelines have established the efficacy of available interventions, but they do not provide detailed guidance for common implementation questions frequently faced in the clinic. An evidence-based guideline was created that addresses several pharmacotherapy-initiation questions that routinely confront treatment teams.. ..The guideline panel formulated five strong recommendations and two conditional recommendations regarding pharmacotherapy… Continue reading Initiating Pharmacologic Treatment in #Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline
Association of Rapid Eye Movement #Sleep With Mortality in Middle-aged and Older Adults
Rapid eye movement (#REM) sleep has been linked with health outcomes, but little is known about the relationship between REM sleep and mortality.. ..The MrOS cohort included 2675 individuals (2675 men [100%]; mean [SD] age, 76.3 [5.5] years) and was followed up for a median (interquartile range) of 12.1 (7.8-13.2) years. The WSC cohort included 1386… Continue reading Association of Rapid Eye Movement #Sleep With Mortality in Middle-aged and Older Adults
Effect of Vitamin #D Supplementation on the Incidence of #Diabetes Mellitus
The effect of vitamin D supplementation on the risk of type 2 diabetes mellitus (T2DM) remains controversial because most randomized controlled trials (RCTs) have been small or have reported low doses of vitamin D.. ..Nine RCTs were included (43 559 participants). The mean age (standard deviation) was 63.5 (6.7) years. The RR for vitamin D… Continue reading Effect of Vitamin #D Supplementation on the Incidence of #Diabetes Mellitus
Women Have a Lower Risk of Nonalcoholic Fatty Liver Disease but a Higher Risk of Progression Vs Men: A Systematic Review and Meta-analysis
The risk of nonalcoholic fatty liver disease (NAFLD) and its progression may differ between men and women. We conducted a systematic review and meta-analysis to determine the relationship between sex and NAFLD, nonalcoholic steatohepatitis (NASH), and advanced NAFLD fibrosis.. ..Our final analysis comprised 54 studies. Samples sizes were 62,239 for the NAFLD analysis, 5428 for… Continue reading Women Have a Lower Risk of Nonalcoholic Fatty Liver Disease but a Higher Risk of Progression Vs Men: A Systematic Review and Meta-analysis
Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease
To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using… Continue reading Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease
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