Poor sleep quality in patients with chronic obstructive pulmonary disease (#COPD ) has been associated with poor health outcomes. However, there is a lack of research on factors associated with sleep disturbance in patients with COPD.. This was a prospective, multicenter cross‐sectional study enrolling a sample of 245 COPD subjects. All patients completed the patient‐reported… Continue reading Factors associated with #sleep disturbance in patients with chronic #obstructive pulmonary disease
Google searches for #suicide and suicide risk factors in the early stages of the #COVID-19 pandemic
A novel coronavirus (SARS-CoV-2), which causes the COVID-19 respiratory illness, emerged in December of 2019 and has since spread globally. The dramatic lifestyle changes and stressors associated with this pandemic pose a threat to mental health and have the potential to exacerbate risk factors for suicide. We used autoregressive integrated moving average (ARIMA) models to… Continue reading Google searches for #suicide and suicide risk factors in the early stages of the #COVID-19 pandemic
#Hyperglycaemia is associated with impaired muscle signalling and #aerobic adaptation to exercise
Increased aerobic exercise capacity, as a result of exercise training, has important health benefits. However, some individuals are resistant to improvements in exercise capacity, probably due to undetermined genetic and environmental factors. Here, we show that exercise-induced improvements in aerobic capacity are blunted and aerobic remodelling of skeletal muscle is impaired in several animal models… Continue reading #Hyperglycaemia is associated with impaired muscle signalling and #aerobic adaptation to exercise
Sex-specific associations between #erythrocyte measures and obstructive #sleep apnea
STUDY OBJECTIVES:Hypoxemic effects of obstructive sleep apnea (OSA) have been implicated in changes in erythropoiesis and hence erythrocyte measures. Sex differences are evident in both OSA and erythropoiesis. Whether sex modulates the relationship between severity of OSA and erythrocyte measures has not previously been studied.. ..RESULTS:In multiple regression models, we found significant interactions between sex… Continue reading Sex-specific associations between #erythrocyte measures and obstructive #sleep apnea
The human #cerebellum has almost 80% of the surface area of the #neocortex
The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. It was computationally reconstructed for the first time to the level of all individual folia from multicontrast high-resolution postmortem MRI scans. Its total shrinkage-corrected surface area (1,590 cm2) was larger than expected or previously reported, equal to 78% of… Continue reading The human #cerebellum has almost 80% of the surface area of the #neocortex
Conservation of #brain connectivity and wiring across the mammalian class
Over 100 years ago, Ramon y Cajal hypothesized that two forces played a role in the evolution of mammalian brain connectivity: minimizing wiring costs and maximizing conductivity speed. Using diffusion MRI, we reconstructed the brain connectomes of 123 mammalian species. Network analysis revealed that both connectivity and the wiring cost are conserved across mammals. We… Continue reading Conservation of #brain connectivity and wiring across the mammalian class
Complementary contributions of non-REM and #REM sleep to visual #learning
Sleep is beneficial for learning. However, it remains unclear whether learning is facilitated by non-rapid eye movement (NREM) sleep or by REM sleep, whether it results from plasticity increases or stabilization, and whether facilitation results from learning-specific processing. Here, we trained volunteers on a visual task and measured the excitatory and inhibitory (E/I) balance in… Continue reading Complementary contributions of non-REM and #REM sleep to visual #learning
Nine-year prospective efficacy and safety of brain-responsive #neurostimulation for focal #epilepsy
Prospectively evaluate safety and efficacy of brain-responsive neurostimulation in adults with medically intractable focal onset seizures (FOS) over 9 years.. Adults treated with brain-responsive neurostimulation within 2 year feasibility or randomized controlled trials enrolled into a long-term prospective open label trial (LTT) to assess safety, efficacy, and quality of life (QOL) over an additional 7… Continue reading Nine-year prospective efficacy and safety of brain-responsive #neurostimulation for focal #epilepsy
Association of triage #hypothermia with in-hospital mortality among patients in the emergency department with suspected #sepsis
To identify if triage hypothermia (<36.0 °C) among emergency department (ED) encounters with sepsis are independently associated with mortality.. ..Of 1.2 billion ED encounters (95% confidence interval [CI] 1.0–1.3 billion), 3.1 million (95% CI 2.7–3.5 million) met the explicit sepsis definition; 7.4% (95% CI 75.2–9.7%) had triage hypothermia. The adjusted odds ratio (aOR) for hypothermia… Continue reading Association of triage #hypothermia with in-hospital mortality among patients in the emergency department with suspected #sepsis
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