Housing characteristics and neighbourhood context are considered risk factors for COVID-19 mortality among older adults. The aim of this study was to investigate how individual-level housing and neighbourhood characteristics are associated with COVID-19 mortality in older adults.. ..Of 279 961 individuals identified to be aged 70 years or older on March 12, 2020, and residing in… Continue reading Residential context and #COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data
Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia
..To investigate the effectiveness of therapies for reducing pain and improving quality of life (QOL) in people with fibromyalgia.. ..A total of 224 trials including 29 962 participants were included. High-quality evidence was found in favor of cognitive behavioral therapy (weighted mean difference [WMD], −0.9; 95% CI, −1.4 to −0.3) for pain in the short term… Continue reading Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia
Sex, age, and hospitalization drive #antibody responses in a #COVID-19 convalescent plasma donor population
Convalescent plasma is a leading treatment for coronavirus disease 2019 (COVID-19), but there is a paucity of data identifying its therapeutic efficacy. Among 126 potential convalescent plasma donors, the humoral immune response was evaluated using a severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) virus neutralization assay with Vero-E6-TMPRSS2 cells; a commercial IgG and IgA ELISA… Continue reading Sex, age, and hospitalization drive #antibody responses in a #COVID-19 convalescent plasma donor population
#Periodontal Inflammation Primes the Systemic Innate #Immune Response
The presence of periodontal diseases (PDs) often strongly correlates with other severe chronic inflammatory conditions, including cardiovascular disease, diabetes, and arthritis. However, the mechanisms through which these diseases interact are unclear. In PD, tissue and bone destruction in the mouth is driven by elevated recruitment of polymorphonuclear neutrophils (PMNs), which are primed and recruited from… Continue reading #Periodontal Inflammation Primes the Systemic Innate #Immune Response
Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, reduced albuminuria in short-term trials involving patients with chronic kidney disease (CKD) and type 2 diabetes. However, its long-term effects on kidney and cardiovascular outcomes are unknown. ..During a median follow-up of 2.6 years, a primary outcome event occurred in 504 of 2833 patients (17.8%) in the finerenone… Continue reading Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
#Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial
This 16-week randomised controlled trial (8-week treatment followed by 8-week follow-up) evaluated the symptomatic improvement in patients with knee osteoarthritis on 3 sessions per week of acupuncture (TSWA) compared to 1 session per week of acupuncture (OSWA). Sixty participants were randomised to either the TSWA or the OSWA group in a 1:1 ratio. The primary… Continue reading #Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial
#Empagliflozin treatment effects across categories of baseline #HbA1c, body #weight and blood #pressure as an add‐on to metformin in patients with type 2 diabetes
In EMPA‐REG MET, in patients with type 2 diabetes mellitus (T2DM) on stable background metformin (≥1500 mg/day), empagliflozin versus placebo significantly improved glycated haemoglobin (HbA1c), body weight (BW), and systolic blood pressure (SBP) over 24 and ≤76 weeks. This analysis investigated empagliflozin treatment effects by baseline cardio‐metabolic factors.. ..In total, 637 patients (56.7% males; mean [SD]… Continue reading #Empagliflozin treatment effects across categories of baseline #HbA1c, body #weight and blood #pressure as an add‐on to metformin in patients with type 2 diabetes
#BMI and All‐Cause #Mortality in a Population‐Based Cohort in Rural South Africa
..The cohort consisted of 9,728 individuals. In adjusted models, those with BMI of 25.0 to 29.9 kg/m2 or 30.0 to 34.9 kg/m2 had a lower hazard of death (adjusted hazard ratio: 0.80; 95% CI: 0.69‐0.92 and adjusted hazard ratio: 0.75; 95% CI: 0.60‐0.93, respectively) compared with those with BMI of 18.5 to 24.9 kg/m2. Conclusions… Continue reading #BMI and All‐Cause #Mortality in a Population‐Based Cohort in Rural South Africa
Trends in #Physician #Voting Practices in California, New York, and Texas, 2006-2018
From 1996 to 2002, eligible physicians voted approximately 9 percentage points less than the general population.1 Since then, physician voter engagement has not been reported. We investigated physician voter participation, voter registration, and voter turnout from 2006 through 2018 in California, New York, and Texas, which are states with the largest number of physicians.. ..Discussion… Continue reading Trends in #Physician #Voting Practices in California, New York, and Texas, 2006-2018
2 Medical News 