Association of #Fluoroquinolone Use With Short-term Risk of Development of Aortic #Aneurysm

Although fluoroquinolones are commonly prescribed antibiotics in the US, recent international studies have shown an increased risk of aortic aneurysm and dissection after fluoroquinolone use, leading to US Food and Drug Administration warnings limiting use for high-risk patients. It is unclear whether these data are true for the US population and who is truly high risk.. ..Of 47 596 545 prescription fills, 9 053 961 (19%) were fluoroquinolones and … Continue reading Association of #Fluoroquinolone Use With Short-term Risk of Development of Aortic #Aneurysm

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Association of Infections and Use of #Fluoroquinolones With the Risk of Aortic #Aneurysm or Aortic Dissection

Prior observational studies have suggested that fluoroquinolone use may be associated with more than 2-fold increased risk of aortic aneurysm or aortic dissection (AA/AD). These studies, however, did not fully consider the role of coexisting infections and the risk of fluoroquinolones relative to other antibiotics.. .. A total of 28 948 cases and 289 480 matched controls were included (71.37% male; mean [SD] age, 67.41 [15.03] years). … Continue reading Association of Infections and Use of #Fluoroquinolones With the Risk of Aortic #Aneurysm or Aortic Dissection

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