Highlights•We assessed the association between sugary drinks and mortality in Japan. •Sugary drink consumption was positively associated with all-cause mortality. •Sugary drinks increased risk of death from circulatory system diseases. AbstractBackgroundFew epidemiologic studies have assessed the associations of sugary drink consumption with mortality outcomes among Asian populations. MethodsThis study included 70,486 participants in the Japan… Continue reading Association of #sugary drink consumption with all-cause and cause-specific #mortality: the Japan Public Health Center-based Prospective Study
#Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis
Neuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD). ObjectivesTo examine the association between neuroticism and risk of PD in a large cohort and a meta‐analysis of prospective cohort studies. MethodsParticipants from the UK Biobank (N = 490,755) completed a neuroticism scale in… Continue reading #Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis
Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at… Continue reading Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
Therapeutic Repurposing of #Biguanides in #Cancer
Biguanides exert antitumor activities through various biochemical mechanisms involving mitochondrial complex I, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and/or mitochondrial glycerophosphate dehydrogenase (mGPD). Biguanides selectively target subpopulations of cancer cells addicted to oxidative phosphorylation (OXPHOS). Metabolic adaptations triggered by biguanide exposure could be potential targets to improve the antitumor efficacy of biguanides.… Continue reading Therapeutic Repurposing of #Biguanides in #Cancer
Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination
The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a year, several vaccines have been developed and millions of doses delivered. Reporting of adverse events is a critical postmarketing activity. METHODS We report findings in 23 patients who presented with thrombosis and… Continue reading Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination
Lower risk of #SARS-CoV2 infection in individuals with severe #mental disorders on #antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population
To the editors, The population with severe mental disorders (SMD) is a medically and socially vulnerable group for a worse outcome in COVID-19. This population has been identified as high-risk group for COVID-19 due to lower awareness of risk, higher prevalence of cognitive impairment and who have limitations to maintain adequate barriers against virus propagation… Continue reading Lower risk of #SARS-CoV2 infection in individuals with severe #mental disorders on #antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population
Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study
To determine treatment effects on the incidence of post-stroke epilepsy (PSE) using different doses of statin, a prospective hospital-based cohort study was designed to explore whether a double-dose statin treatment can better prevent the occurrence of PSE. Methods :A total of 1152 patients with newly diagnosed ischemic stroke admitted to our hospital from March to… Continue reading Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study
The efficacy of #exergaming in people with major #neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial
It is currently unknown whether exergaming is efficacious in people with major neurocognitive disorder (MNCD) residing in long-term care facilities. This pilot randomized controlled trial (RCT) explored the efficacy of a stepping exergame program on gait speed, balance, mobility, reaction time, cognitive and neuropsychiatric outcomes, quality of life, and daily life functioning in people with… Continue reading The efficacy of #exergaming in people with major #neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial
Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials
A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis. Methods For this systematic review and meta-analysis,… Continue reading Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials
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