PurposeTo evaluate the efficacy and safety of Polymyxin B-immobilized hemoperfusion (PMX-HP) against sepsis or septic shock. MethodsWe searched databases (PubMed, EMBASE and Cochrane Library) to identify eligible randomized controlled trials (RCTs). The primary outcomes we included in this review were mortality at the longest follow-up available and serious adverse events associated with treatments. We used… Continue reading Effectiveness of #polymyxin B-immobilized hemoperfusion against #sepsis and septic #shock: A systematic review and meta-analysis
Early-life #environmental exposure determinants of child #behavior in Europe: A longitudinal, population-based study
BackgroundEnvironmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad spectrum of pre- and postnatal environmental exposures on child behavior. Methods and findingsWe used data from the HELIX (Human Early Life Exposome) project, which was… Continue reading Early-life #environmental exposure determinants of child #behavior in Europe: A longitudinal, population-based study
Effectiveness and Harms of High-Flow Nasal #Oxygen for Acute #Respiratory Failure: An Evidence Report for a Clinical Guideline From the American College of Physicians
Use of high-flow nasal oxygen (HFNO) for treatment of adults with acute respiratory failure (ARF) has increased. Purpose:To assess HFNO versus noninvasive ventilation (NIV) or conventional oxygen therapy (COT) for ARF in hospitalized adults. Data Sources:English-language searches of MEDLINE, Embase, CINAHL, and Cochrane Library from January 2000 to July 2020; systematic review reference lists. Study… Continue reading Effectiveness and Harms of High-Flow Nasal #Oxygen for Acute #Respiratory Failure: An Evidence Report for a Clinical Guideline From the American College of Physicians
A Randomized, Open-Label Comparison of Once-Weekly #Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100
Insulin icodec is a novel once-weekly basal insulin analog. This trial investigated the efficacy and safety of icodec using different once-weekly titration algorithms. RESEARCH DESIGN AND METHODS This was a phase 2, randomized, open-label, 16-week, treat-to-target study. Insulin-naïve adults (n = 205) with type 2 diabetes and HbA1c 7–10% while treated with oral glucose-lowering medications… Continue reading A Randomized, Open-Label Comparison of Once-Weekly #Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100
FDA Authorizes Marketing of Device to Facilitate #Muscle Rehabilitation in #Stroke Patients
Today, the U.S. Food and Drug Administration authorized marketing of a new device indicated for use in patients 18 and older undergoing stroke rehabilitation to facilitate muscle re-education and for maintaining or increasing range of motion. The Neurolutions IpsiHand Upper Extremity Rehabilitation System (IpsiHand System) is a Brain-Computer-Interface (BCI) device that assists in rehabilitation for… Continue reading FDA Authorizes Marketing of Device to Facilitate #Muscle Rehabilitation in #Stroke Patients
Association between #periodontitis and severity of #COVID‐19 infection: A case–control study
COVID‐19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID‐19 complications. Materials and MethodsA case–control study was performed using the national electronic health records of the State of Qatar between February and July… Continue reading Association between #periodontitis and severity of #COVID‐19 infection: A case–control study
Physical #activity thresholds for predicting longitudinal gait decline in adults with knee #osteoarthritis
To investigate the longitudinal relationship between physical performance (via real-life accelerometry) and physical capacity (laboratory measurement of gait speed) in patients with knee osteoarthritis (KOA), and to derive accelerometry measured thresholds associated with gait speed decline in KOA that may provide targets for disease-specific physical activity guidelines. DesignLongitudinal data from the Osteoarthritis Initiative (OAI) accelerometer… Continue reading Physical #activity thresholds for predicting longitudinal gait decline in adults with knee #osteoarthritis
Development and validation of a risk prediction model for high-risk #adenomas at the time of first screening #colonoscopy among screening aged Canadians
The aim of this study was to develop a risk prediction model for HRAs detected at screening colonoscopy based on readily available participant information. The cohort consisted of 3035 participants aged 50 to 74 years with no history of cancer who underwent a primary screening colonoscopy at a centralized colon cancer screening centre between 2008 and… Continue reading Development and validation of a risk prediction model for high-risk #adenomas at the time of first screening #colonoscopy among screening aged Canadians
VPS39-deficiency observed in type 2 #diabetes impairs #muscle stem cell differentiation via altered autophagy and epigenetics
Insulin resistance and lower muscle quality (strength divided by mass) are hallmarks of type 2 diabetes (T2D). Here, we explore whether alterations in muscle stem cells (myoblasts) from individuals with T2D contribute to these phenotypes. We identify VPS39 as an important regulator of myoblast differentiation and muscle glucose uptake, and VPS39 is downregulated in myoblasts… Continue reading VPS39-deficiency observed in type 2 #diabetes impairs #muscle stem cell differentiation via altered autophagy and epigenetics
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