Colon cancer (CC) is the third most diagnosed malignancy and second leading cause of cancer mortality globally, with ~ 1.9 million new cases and 903,859 deaths annually (Bray et al. in CA Cancer J Clin 68(6):394–424, 2018). Diet represents a key modifiable risk factor for CC pathogenesis (Herr and Buchler in Cancer Treat Rev 36:377–383, 2010). Cruciferous… Continue reading #Cruciferous #vegetables intake and risk of #colon #cancer: a dose–response meta-analysis
The Effects of the #Mediterranean Diet on #Health and Gut #Microbiota
The Mediterranean Diet (MD) is plant-based and consists of multiple daily portions of vegetables, fruit, cereals, and olive oil. Although there are challenges with isolating the MD from the typical Mediterranean lifestyle and culture (including prolonged ‘social’ meals and siestas), much evidence supports the health benefits of the MD that include improved longevity, reduced metabolic… Continue reading The Effects of the #Mediterranean Diet on #Health and Gut #Microbiota
Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
To examine the dose-response associations of step count and stepping intensity with risk of cardiovascular mortality and incidence of heart failure (HF), myocardial infarction (MI), and stroke (major adverse cardiovascular events, MACE) in people with hypertension.Methods and resultsData were obtained from participants with established hypertension from the UK Biobank accelerometry sub-study. Participants wore a wrist-worn… Continue reading Prospective associations of daily #step count and stepping intensity with overall and type-specific major adverse #cardiovascular events in people with #hypertension
Human #thalamocortical structural connectivity develops in line with a hierarchical axis of #cortical plasticity
Human cortical development follows a hierarchical, sensorimotor-to-association sequence. The brain’s capacity to enact this sequence indicates that it relies on unknown mechanisms to regulate regional differences in the timing of cortical maturation. Given evidence from animal systems that thalamic axons mechanistically regulate periods of cortical plasticity, here we evaluate in humans whether the development of… Continue reading Human #thalamocortical structural connectivity develops in line with a hierarchical axis of #cortical plasticity
Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
Importance Moderate to vigorous–intensity physical activity (MVPA) is essential for primary and secondary prevention of cardiovascular disease (CVD), but long-term patterns around CVD events remain underexplored.Objective To evaluate MVPA trajectories across adulthood, pre-CVD and post-CVD changes, and demographic variations.Design, Setting, and Participants Data were drawn from CARDIA (Coronary Artery Risk Development in Young Adults), a… Continue reading Trajectories of #Physical Activity Before and After #Cardiovascular Disease Events in CARDIA Participants
#Electrophysiological correlates of dynamic #cycling in #Parkinson’s diseaseAuthor
Physical exercise like dynamic cycling has shown promise in enhancing motor function in Parkinson’s disease (PD). We examined the underlying mechanisms of dynamic cycling in PD, emphasizing its impact on the activity of the subthalamic nucleus (STN), a pivotal region within the basal ganglia.MethodsThe investigation involved 100 dynamic cycling sessions conducted among nine PD individuals.… Continue reading #Electrophysiological correlates of dynamic #cycling in #Parkinson’s diseaseAuthor
Global Estimates of #Lives and Life-Years Saved by #COVID-19 #Vaccination During 2020-2024
Importance Estimating global lives and life-years saved is important to put into perspective the benefits of COVID-19 vaccination. Prior studies have focused mainly on the pre-Omicron period or only on specific regions, and lack crucial life-year calculations and often depend on strong modeling assumptions with unaccounted uncertainty.Objective To calculate the lives and life-years saved by… Continue reading Global Estimates of #Lives and Life-Years Saved by #COVID-19 #Vaccination During 2020-2024
#PREVENT Risk Age Equations and Population Distribution in US #Adults
Current US guidelines recommend absolute risk estimation of cardiovascular disease (CVD) to guide decisions on preventive therapies, but communicating absolute risk alone can be challenging for patients and clinicians.1 In 2021, the European Society of Cardiology guidelines added a recommendation to calculate risk age along with absolute risk to improve communication.2 Risk age represents the… Continue reading #PREVENT Risk Age Equations and Population Distribution in US #Adults
Total and specific #potato intake and risk of type 2 #diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts
Objectives To investigate the associations between total and individual potato intake and risk of type 2 diabetes (T2D), estimate the effect on T2D risk of replacing potatoes with whole grains and other major carbohydrate sources, and conduct a dose-response and substitution meta-analysis of prospective cohort studies.Design Prospective cohort study and dose-response meta-analysis of prospective cohort… Continue reading Total and specific #potato intake and risk of type 2 #diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts
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