ObjectivesThe purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome coronavirus 2 infection.BackgroundConcern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. MethodsParticipants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology… Continue reading Prospective Case-Control Study of #Cardiovascular Abnormalities 6 Months Following Mild #COVID-19 in Healthcare Workers
#Cardiovascular symptoms affect the patterns of habitual #coffee consumption
Excessive coffee consumption can lead to unpleasant sensations such as tachycardia and heart palpitations. ObjectivesOur aim was to investigate if cardiovascular symptoms can lead to alterations in habitual patterns of coffee consumption. MethodsWe used information from up to 390,435 European ancestry participants in the UK Biobank, aged 39–73 y. Habitual coffee consumption was self-reported, and… Continue reading #Cardiovascular symptoms affect the patterns of habitual #coffee consumption
#Sarcopenia is independently associated with #parietal atrophy in older adults
Highlights•Sarcopenia was common in old adults living in a retirement community (46.1%). •Sarcopenia had moderate-severe global cortical, parietal and medial temporal atrophy. •Sarcopenia is significantly associated with parietal atrophy in older adults. •Age had a significant relationship with global cortical and medial temporal atrophy. AbstractIntroductionAs populations age, sarcopenia becomes a major health problem among adults… Continue reading #Sarcopenia is independently associated with #parietal atrophy in older adults
Colonization of the #Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
Protein conformational diseases are characterized by misfolding and toxic aggregation of metastable proteins, often culminating in neurodegeneration. Enteric bacteria influence the pathogenesis of neurodegenerative diseases; however, the complexity of the human microbiome hinders our understanding of how individual microbes influence these diseases. Disruption of host protein homeostasis, or proteostasis, affects the onset and progression of… Continue reading Colonization of the #Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes
Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline… Continue reading Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes
Mitigating the threat of emerging #infectious diseases; a coevolutionary perspective
“Nothing in biology makes sense except in the light of evolution”[1] and this is no less true for viral pathogens than it is for their host species. To appreciate the full extent of the challenges posed by current and future emerging infectious diseases (EIDs), I believe it is insightful to take a coevolutionary perspective. Coevolution… Continue reading Mitigating the threat of emerging #infectious diseases; a coevolutionary perspective
Non-steroidal anti-inflammatory drug use and outcomes of #COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study
Early in the pandemic it was suggested that pre-existing use of non-steroidal anti-inflammatory drugs (NSAIDs) could lead to increased disease severity in patients with COVID-19. NSAIDs are an important analgesic, particularly in those with rheumatological disease, and are widely available to the general public without prescription. Evidence from community studies, administrative data, and small studies… Continue reading Non-steroidal anti-inflammatory drug use and outcomes of #COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study
#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer’s disease (AD), we analyzed cross-sectional data from the German Longitudinal Cognitive Impairment and Dementia Study Method: The sample (n=512, mean age: 69.5±5.9 years) included 169 cognitively normal participants and subjects at higher AD risk (53 AD relatives,… Continue reading #Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
Task-Dependent Functional and Effective #Connectivity during Conceptual Processing
Conceptual knowledge is central to cognition. Previous neuroimaging research indicates that conceptual processing involves both modality-specific perceptual-motor areas and multimodal convergence zones. For example, our previous functional magnetic resonance imaging (fMRI) study revealed that both modality-specific and multimodal regions respond to sound and action features of concepts in a task-dependent fashion (Kuhnke P, Kiefer M,… Continue reading Task-Dependent Functional and Effective #Connectivity during Conceptual Processing
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