It has been suggested that rheumatoid arthritis (RA) may originate at the oral mucosa. Our aim was to assess the oral microbiome and the periodontal condition in patients with early rheumatoid arthritis (ERA) and individuals at risk of RA. MethodsThree groups were recruited (50 participants each): (1) ERA patients (2010 ACR/EULAR criteria), (2) at‐risk individuals… Continue reading The oral #microbiome in early #rheumatoid arthritis patients and individuals at risk differs from healthy controls
NOX4 links metabolic regulation in #pancreatic #cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
There is an urgent need to identify vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). PDAC cells acquire metabolic changes that augment NADPH production and cytosolic redox homeostasis. Here, we show that high NADPH levels drive activity of NADPH oxidase 4 (NOX4) expressed in the endoplasmic reticulum (ER) membrane. NOX4 produces H2O2 metabolized by peroxiredoxin 4 (PRDX4)… Continue reading NOX4 links metabolic regulation in #pancreatic #cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
The #COVID-19 #anxiety syndrome scale: Development and psychometric properties
The central aim of our study was to widen the mental health response to the COVID-19 pandemic by developing and evaluating a measure that could be used to identify the presence of anxiety syndrome features associated with COVID-19. In Study 1, a community sample of 292 participants completed the newly developed COVID-19 Anxiety Syndrome Scale… Continue reading The #COVID-19 #anxiety syndrome scale: Development and psychometric properties
#Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset #colorectal cancer among women
Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined. Design In the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake… Continue reading #Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset #colorectal cancer among women
Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
In 2015, a patient in hospice with Alzheimer’s disease (AD) was treated with ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech, movement, and appetite was observed. These improvements were so momentous that she was discharged from the hospice to a long-term care home. Based on this case, we conducted a… Continue reading Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs
The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alterations in microRNAs (miRs) following FMT for rCDI. MethodsSera from two prospective multicentre randomized controlled trials were analyzed for miRNA levels using the Nanostring nCounter platform and quantitative… Continue reading Fecal #microbiota transplantation for recurrent #Clostridioides difficile infection associates with functional alterations in circulating microRNAs
Western-style #diet impedes colonization and clearance of #Citrobacter rodentium
Western-style diet (WSD), which is high in fat and low in fiber, lacks nutrients to support gut microbiota. Consequently, WSD reduces microbiota density and promotes microbiota encroachment, potentially influencing colonization resistance, immune system readiness, and thus host defense against pathogenic bacteria. Here we examined the impact of WSD on infection and colitis in response to… Continue reading Western-style #diet impedes colonization and clearance of #Citrobacter rodentium
MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies
The risk of being exposed to Covid-19 indoors can be as great at 60 feet as it is at 6 feet in a room where the air is mixed.Existing safety guidelines have omitted too many factors to accurately quantify the risk of airborne transmission, such as time, mask use and ventilation rates.Bazant and Bush question… Continue reading MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies
#Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort
Cognitive leisure activity, such as reading, playing mahjong or cards and computer use, is common among older adults in China. Previous studies suggest a negative correlation between cognitive leisure activity and cognitive impairment. However, the relationship between cognitive leisure activity and all-cause mortality has rarely been reported. ObjectivesThis study aims to explore the relationships between… Continue reading #Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort
2 Medical News 