Endovascular renal denervation reduces blood pressure in patients with mild-to-moderate hypertension, but its efficacy in patients with true resistant hypertension has not been shown. We aimed to assess the efficacy and safety of endovascular ultrasound renal denervation in patients with hypertension resistant to three or more antihypertensive medications. MethodsIn a randomised, international, multicentre, single-blind, sham-controlled… Continue reading Ultrasound renal #denervation for #hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial
Comparative Effectiveness of #Aspirin Dosing in #Cardiovascular Disease
The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy. METHODSUsing an open-label, pragmatic design, we randomly assigned patients with established atherosclerotic cardiovascular disease to a strategy of 81 mg or 325 mg… Continue reading Comparative Effectiveness of #Aspirin Dosing in #Cardiovascular Disease
The #overfitted brain: #Dreams evolved to assist generalization
Dreaming remains a mystery to neuroscience. While various hypotheses of why brains evolved nightly dreaming have been put forward, many of these are contradicted by the sparse, hallucinatory, and narrative nature of dreams, a nature that seems to lack any particular function. Recently, research on artificial neural networks has shown that during learning, such networks… Continue reading The #overfitted brain: #Dreams evolved to assist generalization
Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to a significant reduction in body weight gain due to enhanced… Continue reading Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
Mammalian enteral #ventilation ameliorates respiratory failure
Enteral ventilation (EVA) enabled systemic oxygenation in mammaliansEVA improved survival and behaviors in pre-clinical models of respiratory failureEVA yielded no major signs of complications in pre-clinical modelsEVA may serve as a transformative approach in respiratory failure patients Context and significanceThe SARS-CoV-2 pandemic has overwhelmed the clinical need for ventilators and artificial lungs, resulting in a… Continue reading Mammalian enteral #ventilation ameliorates respiratory failure
#Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Calcium (Ca) is an essential nutrient that may play an important role in weight maintenance through its involvement in energy or lipid metabolism. However, little is known about the long-term associations of Ca intake with obesity risk. ObjectivesWe aimed to prospectively examine the association between cumulative Ca intake and the incidence of obesity among American… Continue reading #Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Tracking developmental differences in real-world social #attention across #adolescence, young adulthood and older #adulthood
Detecting and responding appropriately to social information in one’s environment is a vital part of everyday social interactions. Here, we report two preregistered experiments that examine how social attention develops across the lifespan, comparing adolescents (10–19 years old), young (20–40 years old) and older (60–80 years old) adults. In two real-world tasks, participants were immersed… Continue reading Tracking developmental differences in real-world social #attention across #adolescence, young adulthood and older #adulthood
#Smoking is associated with impaired verbal learning and #memory performance in women more than men
Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by exacerbating vascular disease risks. Sex disparities in VCID have been reported, however, few studies have assessed the sex-specific relationships between smoking and memory performance and… Continue reading #Smoking is associated with impaired verbal learning and #memory performance in women more than men
SARS-CoV-2 #Spike Protein Impairs #Endothelial Function via Downregulation of ACE 2
... SARS-CoV-2 infection induces EC inflammation, leading to endotheliitis.1,5 Because S protein decreased ACE2 level and impaired NO bioavailability, we examined whether S protein entry is indispensable for dysfunctional endothelium. As shown in Figure [F], i, the endothelium-dependent vasodilation induced by acetylcholine was impaired in pulmonary arteries isolated from Pseu-Spike-administered hamsters, whereas the endothelium-independent vasodilation… Continue reading SARS-CoV-2 #Spike Protein Impairs #Endothelial Function via Downregulation of ACE 2
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