Rheumatoid arthritis (RA) is a systemic autoimmune disease of multifactorial aetiology, which preferentially affects women. To date, active smoking has been the most reproducibly reported risk factor for anti-citrullinated protein antibodies (ACPA) positive RA, particularly persons who carry the HLA-DRB1-shared epitope (SE) alleles. Objectives: We aimed to investigate the relationships between passive smoking in childhood… Continue reading OP0012 ASSOCIATION BETWEEN PASSIVE #SMOKING IN CHILDHOOD AND ADULTHOOD, AND #RHEUMATOID ARTHRITIS: RESULTS FROM THE FRENCH E3N-EPIC COHORT STUDY
Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey
Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults with COPD. MethodsThis was a population-based cross-sectional study using data from the 2014 and 2016 Korea National Health and Nutrition Examination Survey. Spirometry was used… Continue reading Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey
Predicting #language treatment response in bilingual #aphasia using neural network-based patient models
Predicting language therapy outcomes in bilinguals with aphasia (BWA) remains challenging due to the multiple pre- and poststroke factors that determine the deficits and recovery of their two languages. Computational models that simulate language impairment and treatment outcomes in BWA can help predict therapy response and identify the optimal language for treatment. Here we used… Continue reading Predicting #language treatment response in bilingual #aphasia using neural network-based patient models
#Sleep difficulties, incident #dementia and all-cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study
Sleep difficulties have been implicated in the development and progression of dementia and in all-cause mortality. This study examines the relationship between sleep difficulties, incident dementia and all-cause mortality over 8 years of follow-up among a nationally representative sample of older (≥65 years) adults in the United States. We used data collected from the National… Continue reading #Sleep difficulties, incident #dementia and all-cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study
Potential anti-COVID-19 agents, #cepharanthine and #nelfinavir, and their usage for combination treatment
Nelfinavir (NFV) inhibits SARS-CoV-2 replication•Cepharanthine (CEP) inhibits SARS-CoV-2 attachment to target cells•Combination of NFV and CEP can synergistically augment antiviral activity•NFV and CEP are estimated to shorten the time to viral elimination at clinical doses SummaryAntiviral treatments targeting the coronavirus disease 2019 are urgently required. We screened a panel of already approved drugs in a… Continue reading Potential anti-COVID-19 agents, #cepharanthine and #nelfinavir, and their usage for combination treatment
#Coronary heart disease in mothers and fathers of adult children with #alcohol use disorders
Having a family member with an alcohol use disorder (AUD) may negatively affect a person’s health. Our aim was to study the long-term risk of coronary heart disease (CHD) in parents who have an offspring with AUD. DesignCohort study. Cox regression models and co-sibling analyses. SettingSweden. ParticipantsFrom population registers, we selected all parent-offspring pairs in… Continue reading #Coronary heart disease in mothers and fathers of adult children with #alcohol use disorders
The impact of #caffeine consumption on clinical symptoms in patients with #bipolar disorder: A systematic review
In healthy populations, caffeine appears to have beneficial effects on health; however, patients with bipolar disorder (BD) are routinely advised to limit caffeine use in psychoeducation programmes. We aimed to examine all literature reporting whether caffeine intake/withdrawal impacts the natural course of BD, in terms of clinical outcomes. MethodsPubMed, Embase and PsycINFO were searched (up… Continue reading The impact of #caffeine consumption on clinical symptoms in patients with #bipolar disorder: A systematic review
Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
The relationship of depressive symptoms with kidney function remains poorly investigated. We aimed to evaluate the prospective association between depressive symptoms and rapid decline in kidney function in Chinese adults with normal kidney function. Design, setting, participants, & measurements A total of 4763 participants with eGFR≥60 ml/min per 1.73 m2 at baseline were enrolled from… Continue reading Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
#Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
Our aim was to evaluate the safety and efficacy of a planned therapeutic withdrawal of all antihypertensive and diuretic medications, on commencing a formula low-energy diet replacement, targeting remission of type 2 diabetes. MethodsPost hoc analysis of changes in BP, antihypertensive medication prescriptions and symptoms during the initial total diet replacement phase was performed in… Continue reading #Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
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