Greater whole grain (WG) consumption is associated with reduced risk of cardiovascular disease (CVD); however, few prospective studies have examined WG or refined grain (RG) intake and intermediate cardiometabolic risk factors. ObjectivesWe examined the longitudinal association between WG and RG intake on changes in waist circumference (WC); fasting HDL cholesterol, triglyceride, and glucose concentrations; and… Continue reading Consumption and Longitudinal Changes in #Cardiometabolic Risk Factors in the Framingham Offspring Cohort
#Cognitive Activity and Onset Age of Incident #Alzheimer Disease #Dementia
To test the hypothesis that higher level of cognitive activity predicts older age of dementia onset in Alzheimer's disease (AD) dementia. Methods: As part of a longitudinal cohort study, 1,903 older persons without dementia at enrollment reported their frequency of participation in cognitively stimulating activities. They had annual clinical evaluations to diagnose dementia and AD,… Continue reading #Cognitive Activity and Onset Age of Incident #Alzheimer Disease #Dementia
#Dementia risks identified by vocal features via #telephone conversations: A novel machine learning prediction model
Due to difficulty in early diagnosis of Alzheimer’s disease (AD) related to cost and differentiated capability, it is necessary to identify low-cost, accessible, and reliable tools for identifying AD risk in the preclinical stage. We hypothesized that cognitive ability, as expressed in the vocal features in daily conversation, is associated with AD progression. Thus, we… Continue reading #Dementia risks identified by vocal features via #telephone conversations: A novel machine learning prediction model
Association of ultra-processed #food intake with risk of #inflammatory bowel disease: prospective cohort study
To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD). Design Prospective cohort study. Setting 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China). Participants 116 087 adults aged 35-70 years with… Continue reading Association of ultra-processed #food intake with risk of #inflammatory bowel disease: prospective cohort study
Effects of #Tamoxifen vs. Toremifene on #fatty liver development and lipid profiles in #breast Cancer
Tamoxifen (TAM) and Toremifene (TOR), two kinds of selective estrogen receptor modulators (SERMs), have equal efficacy in breast cancer patients. However, TAM has been proved to affect serum lipid profiles and cause fatty liver disease. The study aimed to compare the effects of TAM and TOR on fatty liver development and lipid profiles. MethodsThis study… Continue reading Effects of #Tamoxifen vs. Toremifene on #fatty liver development and lipid profiles in #breast Cancer
#Metabolic responses to polychromatic #LED and #OLED light at night
Light exposure at night has various implications for human health, but little is known about its effects on energy metabolism during subsequent sleep. We investigated the effects of polychromatic white light using conventional light-emitting diodes (LED) and an alternative light source, organic light-emitting diodes (OLED), producing reduced spectral content in the short wavelength of blue… Continue reading #Metabolic responses to polychromatic #LED and #OLED light at night
Immunotherapy-based targeting of MSLN+ activated portal #fibroblasts is a strategy for treatment of cholestatic liver #fibrosis
Mesothelin (Msln) expression is increased in tissue fibroblasts of damaged liver and other organs and Msln is a common mediator of liver, lung, and kidney fibrosis. We show that anti-Msln immunotoxins kill the Msln-expressing fibroblasts and reduce collagen type I deposition in fibrotic liver, indicating that agents that specifically kill Msln-expressing cells should be a… Continue reading Immunotherapy-based targeting of MSLN+ activated portal #fibroblasts is a strategy for treatment of cholestatic liver #fibrosis
#Cardiovascular drugs and #COVID-19 clinical outcomes: A living systematic review and meta-analysis
The aim of this study was to continually evaluate the association between cardiovascular drug exposure and COVID-19 clinical outcomes (susceptibility to infection, disease severity, hospitalization, hospitalization length, and all-cause mortality) in patients at risk of/with confirmed COVID-19. MethodsEligible publications were identified from more than 500 databases on 1 November 2020. One reviewer extracted data with… Continue reading #Cardiovascular drugs and #COVID-19 clinical outcomes: A living systematic review and meta-analysis
The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep #apnoea severity: A double-blind, placebo-controlled, randomised crossover trial
Recent animal and human physiology studies indicate that noradrenergic and muscarinic processes are key mechanisms that mediate pharyngeal muscle control during sleep. The noradrenergic agent reboxetine combined with the anti-muscarinic hyoscine butylbromide has recently been shown to improve upper airway function during sleep in healthy individuals. However, whether these findings translate to the clinically relevant… Continue reading The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep #apnoea severity: A double-blind, placebo-controlled, randomised crossover trial
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