ObjectiveTo examine the long-term effect of cocoa flavanols on inflammaging biomarkers in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).MethodsCOSMOS is a large, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial testing the effects of a cocoa extract supplement (containing 500 mg cocoa flavanols/day, including 80 mg (−)-epicatechin) among women aged ≥65 years and men aged ≥60… Continue reading Effects of 2-year #cocoa extract# supplementation on #inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial Get access Arrow
Risk markers for sudden unexpected #death in #epilepsy: an observational, prospective, multicentre cohort study
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality. Generalised—particularly nocturnal—convulsive seizures, longstanding epilepsy, and solitary living have been identified retrospectively as risk factors. No definitive electroclinical biomarkers have been prospectively ascertained. This study aimed to identify SUDEP risk markers using multimodality data with long-term follow-up.MethodsThis prospective, multicentre, observational cohort study,… Continue reading Risk markers for sudden unexpected #death in #epilepsy: an observational, prospective, multicentre cohort study
#Nicotinamide for #Skin #Cancer Chemoprevention
Importance Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited.Objective To determine the clinical efficacy of nicotinamide supplementation for skin cancer prevention in the general population and among solid organ transplant recipients.Design, Setting, and Participants A retrospective cohort study was conducted using electronic health record… Continue reading #Nicotinamide for #Skin #Cancer Chemoprevention
Associations of Chronic #Insomnia, Longitudinal #Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults
The relationship between insomnia and cognitive decline is poorly understood. We investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older adults.MethodsFrom the population-based Mayo Clinic Study of Aging, we identified cognitively unimpaired older adults with or without a diagnosis of chronic insomnia who underwent annual neuropsychological assessments (z-scored global cognitive scores… Continue reading Associations of Chronic #Insomnia, Longitudinal #Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults
Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Bacterial DNA from the oral cavity, respiratory tract, gut, and skin has been detected in atherosclerotic plaques, suggesting a role in chronic inflammation linked to atherosclerosis. Chronic bacterial infections often form biofilms resistant to antibiotics and immune detection, giving rise to a new generation of virulent bacteria in suitable conditions. This study explores the role… Continue reading Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Association Between Pro-Inflammatory Potential of #Diet and Inflammatory Parameters in a Group of Patients with Inflammatory #Bowel Disease
Background: The etiopathogenesis of IBD is not fully known; however, both genetic and environmental risk factors, including diet, are contributors to the disease. The present study aimed to determine the effect of dietary inflammatory potential, assessed using the Dietary Inflammatory Index (DII), on disease activity and inflammatory markers, such as IL-6, IL-1β, and IL-10, in… Continue reading Association Between Pro-Inflammatory Potential of #Diet and Inflammatory Parameters in a Group of Patients with Inflammatory #Bowel Disease
Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
IntroductionExergame-based training is emerging as the most effective exercise modality for improving cognition, yet its neural correlates remain largely unexplored. This study explored gray matter (GM) and white matter (WM) changes following the addition of ‘Brain-IT’ training to usual care in mild neurocognitive disorder (mNCD) and their associations with cognitive performance changes.MethodsWe included 41 participants… Continue reading Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
Serum microRNA analysis facilitates decision-making between active surveillance and immediate surgery for low-risk #thyroid #tumors
Objective: To develop a practical and cost-effective test to distinguish patients with malignant thyroid nodules eligible for active surveillance from those requiring immediate surgery.Methods: This prospective observational study included patients with malignant thyroid nodules (3 to 15 mm) who were assigned to either an Active Surveillance Group (n = 30) or a Surgery Group (n… Continue reading Serum microRNA analysis facilitates decision-making between active surveillance and immediate surgery for low-risk #thyroid #tumors
Increasing the #Potassium Level in Patients at High Risk for #Ventricular #Arrhythmias
Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular arrhythmias among patients with cardiovascular disease. An assessment of a strategy of actively increasing plasma potassium levels to the high-normal range is needed.MethodsIn this multicenter, open-label, event-driven, randomized superiority trial conducted in Denmark, we enrolled participants at high risk for ventricular arrhythmias (defined… Continue reading Increasing the #Potassium Level in Patients at High Risk for #Ventricular #Arrhythmias
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