Interventions in preventive cardiology traditionally focus on four standard modifiable cardiovascular risk factors (SMuRFs): hypertension, dyslipidaemia, diabetes mellitus, and smoking. Yet, a substantial proportion of incident cardiovascular events accrues for individuals with none of these factors, particularly among women for whom cardiovascular disease remains under-detected and under-treated. The utility of the inflammatory biomarker high-sensitivity C-reactive… Continue reading #C-reactive protein and #cardiovascular risk among #women with no standard modifiable risk factors: evaluating the ‘SMuRF-less but inflamed’
#Emotion regulation strategies differentially impact memory in #hormonal #contraceptive users
Highlights•HC users show greater emotional reactivity compared to NC females.•Distancing reduces negative affect in HC users compared to NC females.•HC users exhibit memory modulation for emotional images by emotion regulation. AbstractHormonal contraceptives (HCs) are widely used, yet their effects on emotional and cognitive processes remain poorly understood. This study examined how HC use may influence… Continue reading #Emotion regulation strategies differentially impact memory in #hormonal #contraceptive users
The clinical effectiveness of #clarithromycin versus endoscopic sinus surgery for adults with chronic #rhinosinusitis with and without nasal #polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial
SummaryBackgroundA paucity of evidence regarding use of endoscopic sinus surgery and antibiotics in managing chronic rhinosinusitis has contributed to a five-times variation in endoscopic sinus surgery rates, as well as variation in the use of antibiotics. The main aim of the present trial was to compare the clinical effectiveness of endoscopic sinus surgery or 3… Continue reading The clinical effectiveness of #clarithromycin versus endoscopic sinus surgery for adults with chronic #rhinosinusitis with and without nasal #polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial
#Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Background and AimsRecent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF). Whether these recent findings apply equally to women and men remains unknown.MethodsUsing data from REBOOT (tREatment with Beta-blockers after myOcardial infarction withOut reduced ejection fracTion), the largest randomized trial evaluating the effect… Continue reading #Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Personalised #gait retraining for medial compartment #knee #osteoarthritis: a randomised controlled trial
Retraining individuals with medial compartment knee osteoarthritis to walk with a patient-specific change in their foot angle (ie, toe-in or toe-out angle) can reduce excessive joint loading related to disease progression. This study investigated the clinical, biomechanical, and structural efficacy of personalised foot progression angle modifications compared with sham treatment in patients with mild-to-moderate medial… Continue reading Personalised #gait retraining for medial compartment #knee #osteoarthritis: a randomised controlled trial
Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
Psychosocial stress (PSS) is a significant contributor of inflammation and CVD.• NLRP3 inflammasome activation amplifies inflammation in response to PSS.• ER stress is a key upstream mechanism that triggers NLRP3 inflammasome activation.• This study reveals mechanisms and targets to reduce inflammation caused by PSS. AbstractPsychosocial stress (PSS) affects all humans with different intensities and is… Continue reading Psychosocial #stress amplifies inflammation through NLRP3 Inflammasome activated by endoplasmic reticulum stress in the mouse #heart
Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients
This study aimed to investigate the association between dietary vitamin K intake and all-cause mortality in individuals with non-alcoholic fatty liver disease (NAFLD). We analyzed data from 7857 NAFLD participants in the National Health and Nutrition Examination Survey (NHANES 2005–2018) linked to mortality outcomes from the National Death Index (NDI). Dietary vitamin K intake was… Continue reading Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients
The declining #mental #health of the #young and the global disappearance of the #unhappiness hump shape in #age
Across many studies subjective well-being has followed a U-shape in age, declining until people reach middle-age, only to rebound subsequently. Ill-being has followed a mirror-imaged hump-shape. Using graphical and regression analyses of repeat cross-sectional micro-data from the United States and the United Kingdom, we show this empirical regularity has been replaced by a monotonic decrease… Continue reading The declining #mental #health of the #young and the global disappearance of the #unhappiness hump shape in #age
#Mineral Intake and #Depression: A Cross-Sectional Comparative Study Based on National Health and Nutrition Examination Surveys in Korea and the United States
Background/Objectives: Depression is a major global health burden, and previous studies suggest that nutrient deficiencies may contribute to its development. However, research on mineral intake and depression, particularly sodium and potassium, is limited. We conducted a cross-sectional analysis of data from the National Health and Nutrition Examination Survey in Korea (KNHANES) and the United States… Continue reading #Mineral Intake and #Depression: A Cross-Sectional Comparative Study Based on National Health and Nutrition Examination Surveys in Korea and the United States
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