Major depressive disorder (MDD) is related to volumetric decreases in (cortico-)limbic brain regions. In contrast to pharmacological and electroconvulsive therapy, little is known about the brain structural effects of psychotherapy and potential links to symptom improvements. In a naturalistic longitudinal study using structural magnetic resonance tomography, gray matter volume (GMV) and clinical measures were assessed… Continue reading #Limbic gray matter increases in response to #cognitive-behavioral therapy in major #depressive disorder
Breast #milk IgG engages the mouse #neonatal #immune system to instruct responses to #gut #antigens
INTRODUCTIONIn mammals, the early-life period after birth is a time of profound immune development during which the generation of appropriate responses to newly encountered commensal and environmental antigens is crucial for maintaining health. Breast milk is positioned to regulate nascent mucosal immune responses through the delivery of live microbes, commensal-selecting oligosaccharides, maternal cells, and immunomodulatory… Continue reading Breast #milk IgG engages the mouse #neonatal #immune system to instruct responses to #gut #antigens
#Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
INTRODUCTIONInvestigations of retinal biomarkers for #Alzheimer's disease (AD) and AD and related dementias (ADRD), has increased significantly. We examine retinal vascular health in a mouse containing the ADRD risk variant Mthfr677C>T to determine if changes in retina mirror similar changes in cerebrovasculature.METHODSMorphology and function of retinal vasculature and neurons were assessed using in vivo imaging,… Continue reading #Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
#Coffee ’s Impact on #Health and #Well-Being
AbstractCoffee is one of the most widely consumed beverages globally, with over 60% of Americans drinking it daily. This review examines coffee’s multifaceted impact on health and well-being, drawing on decades of research. Overall, the consensus is that moderate coffee intake is more beneficial than harmful across a wide range of health outcomes. Numerous large-scale,… Continue reading #Coffee ’s Impact on #Health and #Well-Being
Temporal Patterns in Out-of-Hospital #Cardiac #Arrest Incidence and Outcome
Question Is the incidence or outcome of out-of-hospital cardiac arrest (OHCA) changing over time overall or among important demographic or clinical groups?Findings In this cohort study including 25 118 individuals, temporal incidence patterns depended on rhythm and demographic characteristics, with some groups experiencing decrease, some increase, and others no change. In contrast, OHCA outcomes improved over… Continue reading Temporal Patterns in Out-of-Hospital #Cardiac #Arrest Incidence and Outcome
#Ultraprocessed or minimally processed diets following healthy dietary guidelines on #weight and cardiometabolic health: a randomized, crossover trial
Ultraprocessed food (UPF) consumption is associated with noncommunicable disease risk, yet no trial has assessed its health impact within the context of national dietary guidelines. In a 2 × 2 crossover randomized controlled feeding trial, 55 adults in England (body mass index ≥25 to <40 kg m−2, habitual UPF intake ≥50% kcal day−1) were provided with two 8-week ad libitum… Continue reading #Ultraprocessed or minimally processed diets following healthy dietary guidelines on #weight and cardiometabolic health: a randomized, crossover trial
#432 Hz Frequency Benefits: A Comprehensive Guide
#Music has always held the power to move, heal, and inspire. But beyond melody and rhythm, the frequencies at which music is tuned can also influence how it affects us. One frequency, in particular, has captured the imagination of musicians, healers, and sound therapists around the world: 432 Hz. Often referred to as the "natural… Continue reading #432 Hz Frequency Benefits: A Comprehensive Guide
The effect of commonly used non- #antibiotic medications on #antimicrobial resistance development in #Escherichia coli
Antimicrobial resistance (AMR) poses a global threat to public health. While antibiotic overuse is a primary driver, emerging evidence suggests that non-antibiotic medications (NAMs) may also contribute. This concern is particularly relevant in residential aged care facilities (RACFs), where both NAMs and antibiotics are frequently used. We investigated whether nine commonly used NAMs in RACFs,… Continue reading The effect of commonly used non- #antibiotic medications on #antimicrobial resistance development in #Escherichia coli
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood #Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice #Guidelines
The “2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults” retires and replaces the “2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.”METHODS:A comprehensive literature search was conducted from December 2023 to June 2024 to identify clinical studies, reviews, and other… Continue reading 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood #Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice #Guidelines
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