The relationship between insomnia and cognitive decline is poorly understood. We investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older adults.MethodsFrom the population-based Mayo Clinic Study of Aging, we identified cognitively unimpaired older adults with or without a diagnosis of chronic insomnia who underwent annual neuropsychological assessments (z-scored global cognitive scores… Continue reading Associations of Chronic #Insomnia, Longitudinal #Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults
Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Bacterial DNA from the oral cavity, respiratory tract, gut, and skin has been detected in atherosclerotic plaques, suggesting a role in chronic inflammation linked to atherosclerosis. Chronic bacterial infections often form biofilms resistant to antibiotics and immune detection, giving rise to a new generation of virulent bacteria in suitable conditions. This study explores the role… Continue reading Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Association Between Pro-Inflammatory Potential of #Diet and Inflammatory Parameters in a Group of Patients with Inflammatory #Bowel Disease
Background: The etiopathogenesis of IBD is not fully known; however, both genetic and environmental risk factors, including diet, are contributors to the disease. The present study aimed to determine the effect of dietary inflammatory potential, assessed using the Dietary Inflammatory Index (DII), on disease activity and inflammatory markers, such as IL-6, IL-1β, and IL-10, in… Continue reading Association Between Pro-Inflammatory Potential of #Diet and Inflammatory Parameters in a Group of Patients with Inflammatory #Bowel Disease
Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
IntroductionExergame-based training is emerging as the most effective exercise modality for improving cognition, yet its neural correlates remain largely unexplored. This study explored gray matter (GM) and white matter (WM) changes following the addition of ‘Brain-IT’ training to usual care in mild neurocognitive disorder (mNCD) and their associations with cognitive performance changes.MethodsWe included 41 participants… Continue reading Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
Serum microRNA analysis facilitates decision-making between active surveillance and immediate surgery for low-risk #thyroid #tumors
Objective: To develop a practical and cost-effective test to distinguish patients with malignant thyroid nodules eligible for active surveillance from those requiring immediate surgery.Methods: This prospective observational study included patients with malignant thyroid nodules (3 to 15 mm) who were assigned to either an Active Surveillance Group (n = 30) or a Surgery Group (n… Continue reading Serum microRNA analysis facilitates decision-making between active surveillance and immediate surgery for low-risk #thyroid #tumors
Increasing the #Potassium Level in Patients at High Risk for #Ventricular #Arrhythmias
Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular arrhythmias among patients with cardiovascular disease. An assessment of a strategy of actively increasing plasma potassium levels to the high-normal range is needed.MethodsIn this multicenter, open-label, event-driven, randomized superiority trial conducted in Denmark, we enrolled participants at high risk for ventricular arrhythmias (defined… Continue reading Increasing the #Potassium Level in Patients at High Risk for #Ventricular #Arrhythmias
A passive and objective measure of recognition memory in mild #cognitive #impairment using Fastball #memory assessment
As viable pharmacotherapies and blood biomarkers emerge for dementia treatment and screening, there remains a great need for accurate, sensitive biomarkers of cognitive function. We have previously demonstrated that Fastball, a new Electroencephalography (EEG) method for the passive and objective measurement of recognition memory that requires no behavioural memory response or task comprehension, is sensitive… Continue reading A passive and objective measure of recognition memory in mild #cognitive #impairment using Fastball #memory assessment
Association Between Consumption of Low- and No-Calorie Artificial #Sweeteners and #Cognitive DeclineAn 8-Year Prospective Study
Background and ObjectivesConsumption of low- and no-calorie sweeteners (LNCSs) has been associated with adverse health outcomes. However, little is known about the association between consumption of LNCSs and cognition. The aim of this study was to investigate the association between consumption of LNCSs and cognitive decline.MethodsWe conducted a longitudinal observational study using data from civil… Continue reading Association Between Consumption of Low- and No-Calorie Artificial #Sweeteners and #Cognitive DeclineAn 8-Year Prospective Study
#Meal timing trajectories in #older adults and their associations with #morbidity, genetic profiles, and #mortality
Older adults are vulnerable to mistimed food intake due to health and environmental changes; characterizing meal timing may inform strategies to promote healthy aging. We investigated longitudinal trajectories of self-reported meal timing in older adults and their associations with morbidity, genetic profiles, and all-cause mortality.MethodsWe analyzed data from 2945 community-dwelling older adults from the University… Continue reading #Meal timing trajectories in #older adults and their associations with #morbidity, genetic profiles, and #mortality
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