We randomly assigned 139 patients with obesity to time-restricted eating (eating only between 8:00 a.m. and 4:00 p.m.) with calorie restriction or daily calorie restriction alone. For 12 months, all the participants were instructed to follow a calorie-restricted diet that consisted of 1500 to 1800 kcal per day for men and 1200 to 1500 kcal… Continue reading Calorie Restriction with or without Time-Restricted Eating in Weight Loss
Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed
... DiscussionThis case illustrates immune-mediated hepatitis secondary to the Moderna vaccine, which on inadvertent re-exposure led to worsening liver injury with deranged synthetic function. This occurred in a well man with no other medical problems. The onset of jaundice associated with the mRNA vaccine was unusually rapid. This was also illustrated in the other cases… Continue reading Immune-mediated hepatitis with the Moderna vaccine, no longer a coincidence but confirmed
Sodium accumulation in breast cancer predicts malignancy and treatment response
BackgroundBreast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (23Na) MRI in preclinical models of breast cancer. MethodsFemale Rag2−/− Il2rg−/− and Balb/c mice bearing orthotopic breast tumours (MDA-MB-231, EMT6 and 4T1) underwent MRI as part of… Continue reading Sodium accumulation in breast cancer predicts malignancy and treatment response
COVID-19 Early Treatment with Non-Steroidal AntiInflammatory Drugs Reduces Hospitalizations andSymptom Duration
BackgroundAt the beginning of the SARS-CoV-2 pandemic we stated that,given the new virus and the little-known disease it caused, in theabsence of Evidence-Based Medicine indications, patients shouldhave been treated with drugs already available, useful to counteractthe pathophysiology of the COVID-19 [1]. Recent literature hasconfirmed that this could be a successful approach, demonstratingthat an early treatment… Continue reading COVID-19 Early Treatment with Non-Steroidal AntiInflammatory Drugs Reduces Hospitalizations andSymptom Duration
Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
Bacteria play a suspected role in the development of several cancer types, and associations between the presence of particular bacteria and prostate cancer have been reported. ObjectiveTo provide improved characterisation of the prostate and urine microbiome and to investigate the prognostic potential of the bacteria present. Design, setting, and participantsMicrobiome profiles were interrogated in sample… Continue reading Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
Auto-immune hepatitis following COVID vaccination
Unprecedented loss of life due to the COVID pandemic has necessitated the development of several vaccines in record time. Most of these vaccines have received approval without being extensively whetted for their adverse effect and efficacy profiles. Most adverse effects have been mild, nonetheless, more serious thromboembolic events have also been reported. Autoimmune hepatitis (AIH)… Continue reading Auto-immune hepatitis following COVID vaccination
Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial
Background. Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies. Intervention studies in patients with moderate to severe COVID-19 have failed to consistently document a beneficial effect. Objective. To determine the efficacy and safety of VD-supplementation in the prevention of SARS-CoV-2 infection in highly exposed… Continue reading Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial
Psychological Distress Before and During the COVID-19 Pandemic Among Adults in the United Kingdom Based on Coordinated Analyses of 11 Longitudinal Studies
How population mental health has evolved across the COVID-19 pandemic under varied lockdown measures is poorly understood, and the consequences for health inequalities are unclear. Objective To investigate changes in mental health and sociodemographic inequalities from before and across the first year of the COVID-19 pandemic in 11 longitudinal studies. Design, Setting, and Participants This… Continue reading Psychological Distress Before and During the COVID-19 Pandemic Among Adults in the United Kingdom Based on Coordinated Analyses of 11 Longitudinal Studies
Elevated Lipoprotein(a) and Risk of Atrial Fibrillation: An Observational and Mendelian Randomization Study
Atrial fibrillation (AF) is a cardiac arrhythmia associated with an elevated risk of stroke, heart failure, and mortality. However, preventative therapies are needed with ancillary benefits on its cardiovascular comorbidities. Lipoprotein(a) (Lp[a]) is a recognized risk factor for atherosclerotic cardiovascular disease (ASCVD), which itself increases AF risk, but it remains unknown whether Lp(a) is a… Continue reading Elevated Lipoprotein(a) and Risk of Atrial Fibrillation: An Observational and Mendelian Randomization Study
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