Caloric restriction (CR) prolongs lifespan, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour-feeding and 22-hour-fasting, raising the question whether calories, fasting, or time of day are causal. We show that 30%-CR is sufficient to extend lifespan 10%; however, a daily fasting interval and circadian-alignment… Continue reading Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
Frequency of adolescent cannabis smoking and vaping in the United States: Trends, disparities and concurrent substance use, 2017–19
AimTo quantify the trends in frequent and occasional cannabis vaping, demographic differences and concurrent nicotine and alcohol use. DesignObservational study. Survey-weighted multinomial logistic regression models assessed trends and disparities in past 30-day cannabis use. Trends were assessed overall and by sex, race/ethnicity, parental education and urbanicity. Multinomial logistic regression models also estimated associations of cannabis… Continue reading Frequency of adolescent cannabis smoking and vaping in the United States: Trends, disparities and concurrent substance use, 2017–19
Supper Timing and Cardiovascular Mortality: The Japan Collaborative Cohort Study
Evidence on the role of supper timing in the development of cardiovascular disease (CVD) is limited. In this study, we examined the associations between supper timing and risks of mortality from stroke, coronary heart disease (CHD), and total CVD. A total of 28,625 males and 43,213 females, aged 40 to 79 years, free from CVD… Continue reading Supper Timing and Cardiovascular Mortality: The Japan Collaborative Cohort Study
Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26
SignificanceGenome-wide association studies have identified two major risk loci for age-related macular degeneration (AMD) on chromosome (Chr) 1 and Chr10. Here, we use proteomics to analyze submacular stromal tissue punches from older eye donors without AMD, comparing tissue from donors who were homozygous for high-risk alleles at Chr1 or Chr10 with tissue from donors with… Continue reading Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26
Blood Pressure Increase following COVID-19 Vaccination: A Systematic Overview and Meta-Analysis
AbstractCoronavirus disease 2019 (COVID-19) vaccines proved a strong clinical efficacy against symptomatic or moderate/severe COVID-19 and are considered the most promising approach for curbing the pandemic. However, some questions regarding the safety of COVID-19 vaccines have been recently raised. Among adverse events to vaccines and despite a lack of signal during phase III clinical trials,… Continue reading Blood Pressure Increase following COVID-19 Vaccination: A Systematic Overview and Meta-Analysis
Metacognitions and brooding predict depressive symptoms in a community adolescent sample
Depressive symptoms are prevalent in adolescence, and girls have higher levels of depressive symptoms and depressive disorder than boys. Rumination and especially brooding, seem to be a central maintaining factor of depressive symptoms, where metacognitions about rumination play a prominent role in maintaining depressive rumination. There is a sex difference in adults in depressive disorder.… Continue reading Metacognitions and brooding predict depressive symptoms in a community adolescent sample
Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients?
To the Editor,On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), commonly known as paracetamol, induces or worsens glutathione (GSH) consumption in elderly patients affected by early or mild coronavirus disease 2019 (COVID-19), thus greatly enhancing the risk of COVID-19 exacerbation in these patients.1 By early COVID-19, we mean the typical or commonly acknowledged… Continue reading Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients?
Are there outcome differences between NAFLD and metabolic-associated fatty liver disease?
BackgroundGiven the association of NAFLD with metabolic risks, a name change to MAFLD is proposed. We compared the long-term outcomes of NAFLD and MAFLD. MethodsWe included patients with fatty liver disease (FLD) from NHANES III and NHANES 2017–2018 (FLD defined as moderate to severe hepatic steatosis by ultrasound for NHANES III and as having a… Continue reading Are there outcome differences between NAFLD and metabolic-associated fatty liver disease?
Alopecia areata following COVID-19 vaccination: vaccine-induced autoimmunity?
Dear Editor, We report a case of an 80-year-old man who came to our attention for a rapidly progressive loss of facial hair 7 days after the administration of the first dose of the BNT162b2 vaccine, an mRNA vaccine against SARS-CoV-2. He had no personal or family history of alopecia or autoimmunity. Before the vaccination, a… Continue reading Alopecia areata following COVID-19 vaccination: vaccine-induced autoimmunity?
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