Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients?

To the Editor,On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), commonly known as paracetamol, induces or worsens glutathione (GSH) consumption in elderly patients affected by early or mild coronavirus disease 2019 (COVID-19), thus greatly enhancing the risk of COVID-19 exacerbation in these patients.1 By early COVID-19, we mean the typical or commonly acknowledged …

Continue reading Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients?

Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension

AimsPrevious studies have found high sodium intake to be associated with increased risks of cardiovascular disease (CVD) and all-cause mortality among individuals with hypertension; findings on the effect of intake among individuals without hypertension have been equivocal. We aimed to compare the risks of incident CVD and all-cause mortality among initiators of sodium-containing acetaminophen with …

Continue reading Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension

Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients?

On October 2020, Sestili and Fimognari reported that acetaminophen (N-aetyl-para-aminophenol), commonly known as paracetamol, induces or worsens glutathione (GSH) consumption in elderly patients affected by early or mild coronavirus disease 2019 (COVID-19), thus greatly enhancing the risk of COVID-19 exacerbation in these patients.1 By early COVID-19, we mean the typical or commonly acknowledged symptomatology associated …

Continue reading Paracetamol in the home treatment of early COVID-19 symptoms: A possible foe rather than a friend for elderly patients?

Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study

Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≀6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe …

Continue reading Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study

Comparison of #Acetaminophen (Paracetamol) With #Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children. Despite the common use of these medications, treatment recommendations for young children remain divergent.. ..Overall, 19 studies (11 randomized; 8 nonrandomized) of 241β€―138 participants from 7 countries and various health care settings (hospital-based and …

Continue reading Comparison of #Acetaminophen (Paracetamol) With #Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years