Aspirin intake has been shown to lead to significant protection against colorectalcancer, for example with an up to twofold reduction in colorectal adenoma incidence rates at higherdoses. The mechanisms contributing to protection are not yet fully understood. While aspirin isan anti-inflammatory drug and can thus influence the tumor microenvironment, in vitro and in vivoexperiments have… Continue reading Aspirin’s effect on kinetic parameters ofcells contributes to its role in reducingincidence of advanced colorectaladenomas, shown by a multiscalecomputational study
Gender Dysphoria and Suicidal Ideation: Clinical Observations from a Psychiatric Emergency Service
Adolescent gender dysphoria is increasingly common. There has been documentation of the association of gender dysphoria with numerous other psychiatric conditions as well as attempted and completed suicide. The literature is unsettled on specific risk factors for self-harm within this population. Though there are published recommendations, there appears to be a need for additional clinical… Continue reading Gender Dysphoria and Suicidal Ideation: Clinical Observations from a Psychiatric Emergency Service
Had COVID? You’ll probably make antibodies for a lifetime
People who recover from mild COVID-19 have bone-marrow cells that can churn out antibodies for decades, although viral variants could dampen some of the protection they offer. Many people who have been infected with SARS-CoV-2 will probably make antibodies against the virus for most of their lives. So suggest researchers who have identified long-lived antibody-producing… Continue reading Had COVID? You’ll probably make antibodies for a lifetime
Effect of Duloxetine on Opioid Use after Total Knee Arthroplasty. A Double-Blinded Randomized Control Trial
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Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death
The intestinal microbiome releases a plethora of small molecules. Here, we show that the Ruminococcaceae metabolite isoamylamine (IAA) is enriched in aged mice and elderly people, whereas Ruminococcaceae phages, belonging to the Myoviridae family, are reduced. Young mice orally administered IAA show cognitive decline, whereas Myoviridae phage administration reduces IAA levels. Mechanistically, IAA promotes apoptosis… Continue reading Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death
Burnout in emergency medicine professionals after 2 years of the COVID-19 pandemic: a threat to the healthcare system?
AbstractBackground: Burnout is a common problem among healthcare professionals (HCPs), in particular young doctors and nurses working in emergency medical services. The coronavirus disease 2019 (COVID-19) pandemic has generated a substantial increase in the workload of those working in front-line services, and there is evidence of physical and mental distress among professionals that may have… Continue reading Burnout in emergency medicine professionals after 2 years of the COVID-19 pandemic: a threat to the healthcare system?
Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals with Anorexia Nervosa – A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
BackgroundThe pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in grey matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy controls. Recent weight regain before scanning may explain some of this… Continue reading Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals with Anorexia Nervosa – A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
Adverse effects of COVID-19 vaccines and measures to prevent them
Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals. According to European Medicines Agency recommendations, frequent COVID-19… Continue reading Adverse effects of COVID-19 vaccines and measures to prevent them
Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort study
Objectives Asthma is one of the greatest health burdens, yet contributors to asthma symptom trajectories are understudied in Australian children. We aimed to assess the trajectories of asthma symptom and their associations with several family environmental factors during the childhood period in Australia. Design Secondary analysis from a cross-sequential cohort study. Setting Nationwide representative data… Continue reading Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort study
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