Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals. According to European Medicines Agency recommendations, frequent COVID-19… Continue reading Adverse effects of COVID-19 vaccines and measures to prevent them
Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort study
Objectives Asthma is one of the greatest health burdens, yet contributors to asthma symptom trajectories are understudied in Australian children. We aimed to assess the trajectories of asthma symptom and their associations with several family environmental factors during the childhood period in Australia. Design Secondary analysis from a cross-sequential cohort study. Setting Nationwide representative data… Continue reading Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort study
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Phenome-wide association study (MR-PheWAS) using clinical and genetic data from a national healthcare system biobank. Methods and findingsAnalyses were performed using data from… Continue reading A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
May 2022 : Peculiar Evolution of the Monkeypox Virus Genomes
We compare the evolution of 14 monkeypox virus genomes til that of May 2022 that is currently spreading across humans in numerous countries outside Africa. Our aim was to discover mutations or other viral evolutions (recombination) that may explain the sudden impact of this very low-level circulating epidemic or alert on a potential peculiar pathogenic… Continue reading May 2022 : Peculiar Evolution of the Monkeypox Virus Genomes
Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts
BackgroundAlthough 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality.MethodsIn this meta-analysis, we identified studies investigating the effect of daily step count on all-cause mortality in adults… Continue reading Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts
1,287,595 Injuries Reported After COVID Shots, Vaccine Injury Compensation Programs ‘Overwhelmed’
The Centers for Disease Control and Prevention (CDC) today released new data showing a total of 1,287,595 reports of adverse events following COVID-19 vaccines were submitted between Dec. 14, 2020, and May 27, 2022, to the Vaccine Adverse Event Reporting System (VAERS). That’s an increase of 9,615 adverse events over the previous week. VAERS is… Continue reading 1,287,595 Injuries Reported After COVID Shots, Vaccine Injury Compensation Programs ‘Overwhelmed’
Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation
Neuropathic pain affects millions of people worldwide, yet the molecular mechanisms of how it develops and persists are poorly understood. Given that males have historically been utilized as the primary sex in preclinical studies, less is known about the female neuroinflammatory response to injury, formation of pain, or response to pain-relieving therapies. Macrophages contribute to… Continue reading Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation
Long COVID after breakthrough SARS-CoV-2 infection
The post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—also referred to as Long COVID—have been described, but whether breakthrough SARS-CoV-2 infection (BTI) in vaccinated people results in post-acute sequelae is not clear. In this study, we used the US Department of Veterans Affairs national healthcare databases to build a cohort of 33,940… Continue reading Long COVID after breakthrough SARS-CoV-2 infection
Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity
Importance Obesity increases the incidence and mortality from some types of cancer, but it remains uncertain whether intentional weight loss can decrease this risk. Objective To investigate whether bariatric surgery is associated with lower cancer risk and mortality in patients with obesity. Design, Setting, and Participants In the SPLENDID (Surgical Procedures and Long-term Effectiveness in… Continue reading Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity
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